Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants

The glucosylation of pollutant and pesticide metabolites in plants controls their bioactivity and the formation of subsequent chemical residues. The model plant Arabidopsis thaliana contains >100 glycosyltransferases (GTs) dedicated to small-molecule conjugation and, whereas 44 of these enzymes c...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-12, Vol.104 (51), p.20238-20243
Hauptverfasser:	Brazier-Hicks, Melissa, Offen, Wendy A, Gershater, Markus C, Revett, Timothy J, Lim, Eng-Kiat, Bowles, Dianna J, Davies, Gideon J, Edwards, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Arabidopsis - chemistry Arabidopsis - genetics Arabidopsis Proteins - chemistry Arabidopsis Proteins - classification Arabidopsis Proteins - genetics Arabidopsis thaliana aromatic compounds bifunctional enzymes Biochemistry Biological Sciences Brassica napus Brassica napus - enzymology Brassica napus - genetics Catalysis Chemical compounds chlorinated phenols chloroanilines crystal structure enzyme activity Enzymes Flowers & plants glucosyltransferases Glucosyltransferases - chemistry Glucosyltransferases - classification Glucosyltransferases - genetics glycosyltransferases Glycosyltransferases - chemistry Glycosyltransferases - classification Glycosyltransferases - genetics Hydroxyls Kinetics Metabolism Models, Molecular Molecular Sequence Data Mutagenesis mutants Mutation N-glucosyltransferase O-glucosyltransferase organochlorine compounds Phenols Phylogeny Plants Protein Conformation Protein Engineering Proteins Sugars Xenobiotics Xenobiotics - metabolism
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