Sensitivity of HIV-1 to Entry Inhibitors Correlates with Envelope/Coreceptor Affinity, Receptor Density, and Fusion Kinetics

HIV entry inhibitors include coreceptor antagonists and the fusion inhibitor T-20. T-20 binds the first helical region (HR1) in the gp41 subunit of the viral envelope (Env) protein and prevents conformational changes required for membrane fusion. HR1 appears to become accessible to T-20 after Env bi...

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