Inflammatory Mediators are Perpetuated in Macrophages Resistant to Apoptosis Induced by Hypoxia

A hypoxic/anoxic microenvironment has been proposed to exist within a vascular lesion due to intimal or medial cell proliferation in vascular diseases. Here, we examined whether hypoxia alters macrophage function by exposing murine macrophage-like RAW 264.7 (RAW) cells to hypoxia (2% O2). When cells...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-12, Vol.94 (25), p.13903-13908
Hauptverfasser:	Yun, Jong K., McCormick, Thomas S., Villabona, Claudia, Judware, Raymond R., Espinosa, Maria B., Lapetina, Eduardo G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaerobic conditions Animals Apoptosis Apoptosis - physiology Biological Sciences Cardiovascular disease Carrier Proteins - metabolism Cell Hypoxia - physiology Cell Line Cell lines Cultured cells Endoplasmic Reticulum Chaperone BiP Foam cells Heat shock proteins HSC70 Heat-Shock Proteins HSP70 Heat-Shock Proteins - metabolism Hypoxia Inflammation Mediators - metabolism Lesions Lipoproteins, LDL - metabolism Macrophages Macrophages - cytology Macrophages - metabolism Medical research Mice Microscopy, Confocal Molecular Chaperones - metabolism Oxygen PC12 cells Tumor Necrosis Factor-alpha - biosynthesis
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