POU Domain Factor Brn-3b is Required for the Development of a Large Set of Retinal Ganglion Cells

The three members of the Brn-3 family of POU domain transcription factors are found in highly restricted sets of central nervous system neurons. Within the retina, these factors are present only within subsets of ganglion cells. We show here that in the developing mouse retina, Brn-3b protein is fir...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-04, Vol.93 (9), p.3920-3925
Hauptverfasser:	Gan, Lin, Xiang, Mengqing, Zhou, Lijuan, Wagner, Daniel S., Klein, William H., Nathans, Jeremy
Format:	Artikel
Sprache:	eng
Schlagworte:	Amacrine cells Animals Animals, Newborn Brain - cytology Brain - embryology Cell Division Cell nucleus Cellular differentiation Cellular immunity Developmental biology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic and Fetal Development Exons Ganglia Genes Genotype Heterozygote Homozygote Mice Mice, Inbred C57BL Mice, Knockout Nerve Fibers - physiology Nerve Fibers - ultrastructure Neurons Neurons - cytology Neurons - physiology Optic Nerve - cytology Optic Nerve - embryology Photoreceptors Polymerase Chain Reaction Proteins Retina Retina - cytology Retina - embryology Retinal Ganglion Cells - cytology Retinal Ganglion Cells - physiology Rodents Stem Cells Transcription Factor Brn-3 Transcription Factor Brn-3B Transcription Factors - genetics Transcription Factors - metabolism
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