POU Domain Factor Brn-3b is Required for the Development of a Large Set of Retinal Ganglion Cells
The three members of the Brn-3 family of POU domain transcription factors are found in highly restricted sets of central nervous system neurons. Within the retina, these factors are present only within subsets of ganglion cells. We show here that in the developing mouse retina, Brn-3b protein is fir...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1996-04, Vol.93 (9), p.3920-3925 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3925 |
|---|---|
| container_issue | 9 |
| container_start_page | 3920 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 93 |
| creator | Gan, Lin Xiang, Mengqing Zhou, Lijuan Wagner, Daniel S. Klein, William H. Nathans, Jeremy |
| description | The three members of the Brn-3 family of POU domain transcription factors are found in highly restricted sets of central nervous system neurons. Within the retina, these factors are present only within subsets of ganglion cells. We show here that in the developing mouse retina, Brn-3b protein is first observed in presumptive ganglion cell precursors as they begin to migrate from the zone of dividing neuroblasts to the future ganglion cell layer, and that targeted disruption of the Brn-3b gene leads in the homozygous state to a selective loss of 70% of retinal ganglion cells. In Brn-3b (-/-) mice other neurons within the retina and brain are minimally or not at all affected. These experiments indicate that Brn-3b plays an essential role in the development of specific ganglion cell types. |
| doi_str_mv | 10.1073/pnas.93.9.3920 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_journals_201417561</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>39168</jstor_id><sourcerecordid>39168</sourcerecordid><originalsourceid>FETCH-LOGICAL-c579t-9b3a6a55443bf8b1670142e17f817b127562671371f67bf60b10fac03fcce9f43</originalsourceid><addsrcrecordid>eNqFUk1v0zAYthBolMGVAxKSxWG3hNdx4g-JC3RsIFUaGuxsOZndpXLszk4m-Pc4tFSFA5ws-_nw-_gxQi8JlAQ4fbv1OpWSlrKksoJHaEFAkoLVEh6jBUDFC1FX9VP0LKUNAMhGwAk6EYxWUsIC6S9XN_g8DLr3-EJ3Y4j4Q_QFbXGf8LW5n_pobrHNx-OdwefmwbiwHYwfcbBY45WOa4O_ml_bazP2Xjt8qf3a9cHjpXEuPUdPrHbJvNivp-jm4uO35adidXX5efl-VXQNl2MhW6qZbpq6pq0VLWEcSF0Zwq0gvCUVb1jFOKGcWMZby6AlYHUH1Hadkbamp-jdznc7tYO57fKMUTu1jf2g4w8VdK_-RHx_p9bhQVFZM8jys708hvvJpFENfepyAO1NmJLiAvLlDfkvkTSCCQ6z45u_iJswxfxASVU5G8mJZrdyR-piSCkaexiYgJoLVnPBSlIl1VxwFrw-jnmg7xs9wmfdb_RYf_YvXNnJudF8HzPx1Y64SflXHJhUEiboTw3kwIw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201417561</pqid></control><display><type>article</type><title>POU Domain Factor Brn-3b is Required for the Development of a Large Set of Retinal Ganglion Cells</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Gan, Lin ; Xiang, Mengqing ; Zhou, Lijuan ; Wagner, Daniel S. ; Klein, William H. ; Nathans, Jeremy</creator><creatorcontrib>Gan, Lin ; Xiang, Mengqing ; Zhou, Lijuan ; Wagner, Daniel S. ; Klein, William H. ; Nathans, Jeremy</creatorcontrib><description>The three members of the Brn-3 family of POU domain transcription factors are found in highly restricted sets of central nervous system neurons. Within the retina, these factors are present only within subsets of ganglion cells. We show here that in the developing mouse retina, Brn-3b protein is first observed in presumptive ganglion cell precursors as they begin to migrate from the zone of dividing neuroblasts to the future ganglion cell layer, and that targeted disruption of the Brn-3b gene leads in the homozygous state to a selective loss of 70% of retinal ganglion cells. In Brn-3b (-/-) mice other neurons within the retina and brain are minimally or not at all affected. These experiments indicate that Brn-3b plays an essential role in the development of specific ganglion cell types.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.93.9.3920</identifier><identifier>PMID: 8632990</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Amacrine cells ; Animals ; Animals, Newborn ; Brain - cytology ; Brain - embryology ; Cell Division ; Cell nucleus ; Cellular differentiation ; Cellular immunity ; Developmental biology ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Embryonic and Fetal Development ; Exons ; Ganglia ; Genes ; Genotype ; Heterozygote ; Homozygote ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Nerve Fibers - physiology ; Nerve Fibers - ultrastructure ; Neurons ; Neurons - cytology ; Neurons - physiology ; Optic Nerve - cytology ; Optic Nerve - embryology ; Photoreceptors ; Polymerase Chain Reaction ; Proteins ; Retina ; Retina - cytology ; Retina - embryology ; Retinal Ganglion Cells - cytology ; Retinal Ganglion Cells - physiology ; Rodents ; Stem Cells ; Transcription Factor Brn-3 ; Transcription Factor Brn-3B ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1996-04, Vol.93 (9), p.3920-3925</ispartof><rights>Copyright 1996 National Academy of Sciences</rights><rights>Copyright National Academy of Sciences Apr 30, 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c579t-9b3a6a55443bf8b1670142e17f817b127562671371f67bf60b10fac03fcce9f43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/93/9.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/39168$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/39168$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8632990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gan, Lin</creatorcontrib><creatorcontrib>Xiang, Mengqing</creatorcontrib><creatorcontrib>Zhou, Lijuan</creatorcontrib><creatorcontrib>Wagner, Daniel S.</creatorcontrib><creatorcontrib>Klein, William H.</creatorcontrib><creatorcontrib>Nathans, Jeremy</creatorcontrib><title>POU Domain Factor Brn-3b is Required for the Development of a Large Set of Retinal Ganglion Cells</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The three members of the Brn-3 family of POU domain transcription factors are found in highly restricted sets of central nervous system neurons. Within the retina, these factors are present only within subsets of ganglion cells. We show here that in the developing mouse retina, Brn-3b protein is first observed in presumptive ganglion cell precursors as they begin to migrate from the zone of dividing neuroblasts to the future ganglion cell layer, and that targeted disruption of the Brn-3b gene leads in the homozygous state to a selective loss of 70% of retinal ganglion cells. In Brn-3b (-/-) mice other neurons within the retina and brain are minimally or not at all affected. These experiments indicate that Brn-3b plays an essential role in the development of specific ganglion cell types.</description><subject>Amacrine cells</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Brain - cytology</subject><subject>Brain - embryology</subject><subject>Cell Division</subject><subject>Cell nucleus</subject><subject>Cellular differentiation</subject><subject>Cellular immunity</subject><subject>Developmental biology</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Embryonic and Fetal Development</subject><subject>Exons</subject><subject>Ganglia</subject><subject>Genes</subject><subject>Genotype</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Nerve Fibers - physiology</subject><subject>Nerve Fibers - ultrastructure</subject><subject>Neurons</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Optic Nerve - cytology</subject><subject>Optic Nerve - embryology</subject><subject>Photoreceptors</subject><subject>Polymerase Chain Reaction</subject><subject>Proteins</subject><subject>Retina</subject><subject>Retina - cytology</subject><subject>Retina - embryology</subject><subject>Retinal Ganglion Cells - cytology</subject><subject>Retinal Ganglion Cells - physiology</subject><subject>Rodents</subject><subject>Stem Cells</subject><subject>Transcription Factor Brn-3</subject><subject>Transcription Factor Brn-3B</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v0zAYthBolMGVAxKSxWG3hNdx4g-JC3RsIFUaGuxsOZndpXLszk4m-Pc4tFSFA5ws-_nw-_gxQi8JlAQ4fbv1OpWSlrKksoJHaEFAkoLVEh6jBUDFC1FX9VP0LKUNAMhGwAk6EYxWUsIC6S9XN_g8DLr3-EJ3Y4j4Q_QFbXGf8LW5n_pobrHNx-OdwefmwbiwHYwfcbBY45WOa4O_ml_bazP2Xjt8qf3a9cHjpXEuPUdPrHbJvNivp-jm4uO35adidXX5efl-VXQNl2MhW6qZbpq6pq0VLWEcSF0Zwq0gvCUVb1jFOKGcWMZby6AlYHUH1Hadkbamp-jdznc7tYO57fKMUTu1jf2g4w8VdK_-RHx_p9bhQVFZM8jys708hvvJpFENfepyAO1NmJLiAvLlDfkvkTSCCQ6z45u_iJswxfxASVU5G8mJZrdyR-piSCkaexiYgJoLVnPBSlIl1VxwFrw-jnmg7xs9wmfdb_RYf_YvXNnJudF8HzPx1Y64SflXHJhUEiboTw3kwIw</recordid><startdate>19960430</startdate><enddate>19960430</enddate><creator>Gan, Lin</creator><creator>Xiang, Mengqing</creator><creator>Zhou, Lijuan</creator><creator>Wagner, Daniel S.</creator><creator>Klein, William H.</creator><creator>Nathans, Jeremy</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19960430</creationdate><title>POU Domain Factor Brn-3b is Required for the Development of a Large Set of Retinal Ganglion Cells</title><author>Gan, Lin ; Xiang, Mengqing ; Zhou, Lijuan ; Wagner, Daniel S. ; Klein, William H. ; Nathans, Jeremy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c579t-9b3a6a55443bf8b1670142e17f817b127562671371f67bf60b10fac03fcce9f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Amacrine cells</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Brain - cytology</topic><topic>Brain - embryology</topic><topic>Cell Division</topic><topic>Cell nucleus</topic><topic>Cellular differentiation</topic><topic>Cellular immunity</topic><topic>Developmental biology</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Embryonic and Fetal Development</topic><topic>Exons</topic><topic>Ganglia</topic><topic>Genes</topic><topic>Genotype</topic><topic>Heterozygote</topic><topic>Homozygote</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Nerve Fibers - physiology</topic><topic>Nerve Fibers - ultrastructure</topic><topic>Neurons</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>Optic Nerve - cytology</topic><topic>Optic Nerve - embryology</topic><topic>Photoreceptors</topic><topic>Polymerase Chain Reaction</topic><topic>Proteins</topic><topic>Retina</topic><topic>Retina - cytology</topic><topic>Retina - embryology</topic><topic>Retinal Ganglion Cells - cytology</topic><topic>Retinal Ganglion Cells - physiology</topic><topic>Rodents</topic><topic>Stem Cells</topic><topic>Transcription Factor Brn-3</topic><topic>Transcription Factor Brn-3B</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gan, Lin</creatorcontrib><creatorcontrib>Xiang, Mengqing</creatorcontrib><creatorcontrib>Zhou, Lijuan</creatorcontrib><creatorcontrib>Wagner, Daniel S.</creatorcontrib><creatorcontrib>Klein, William H.</creatorcontrib><creatorcontrib>Nathans, Jeremy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gan, Lin</au><au>Xiang, Mengqing</au><au>Zhou, Lijuan</au><au>Wagner, Daniel S.</au><au>Klein, William H.</au><au>Nathans, Jeremy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>POU Domain Factor Brn-3b is Required for the Development of a Large Set of Retinal Ganglion Cells</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1996-04-30</date><risdate>1996</risdate><volume>93</volume><issue>9</issue><spage>3920</spage><epage>3925</epage><pages>3920-3925</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The three members of the Brn-3 family of POU domain transcription factors are found in highly restricted sets of central nervous system neurons. Within the retina, these factors are present only within subsets of ganglion cells. We show here that in the developing mouse retina, Brn-3b protein is first observed in presumptive ganglion cell precursors as they begin to migrate from the zone of dividing neuroblasts to the future ganglion cell layer, and that targeted disruption of the Brn-3b gene leads in the homozygous state to a selective loss of 70% of retinal ganglion cells. In Brn-3b (-/-) mice other neurons within the retina and brain are minimally or not at all affected. These experiments indicate that Brn-3b plays an essential role in the development of specific ganglion cell types.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8632990</pmid><doi>10.1073/pnas.93.9.3920</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1996-04, Vol.93 (9), p.3920-3925 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_journals_201417561 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amacrine cells Animals Animals, Newborn Brain - cytology Brain - embryology Cell Division Cell nucleus Cellular differentiation Cellular immunity Developmental biology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Embryonic and Fetal Development Exons Ganglia Genes Genotype Heterozygote Homozygote Mice Mice, Inbred C57BL Mice, Knockout Nerve Fibers - physiology Nerve Fibers - ultrastructure Neurons Neurons - cytology Neurons - physiology Optic Nerve - cytology Optic Nerve - embryology Photoreceptors Polymerase Chain Reaction Proteins Retina Retina - cytology Retina - embryology Retinal Ganglion Cells - cytology Retinal Ganglion Cells - physiology Rodents Stem Cells Transcription Factor Brn-3 Transcription Factor Brn-3B Transcription Factors - genetics Transcription Factors - metabolism |
| title | POU Domain Factor Brn-3b is Required for the Development of a Large Set of Retinal Ganglion Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T06%3A56%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=POU%20Domain%20Factor%20Brn-3b%20is%20Required%20for%20the%20Development%20of%20a%20Large%20Set%20of%20Retinal%20Ganglion%20Cells&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Gan,%20Lin&rft.date=1996-04-30&rft.volume=93&rft.issue=9&rft.spage=3920&rft.epage=3925&rft.pages=3920-3925&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.93.9.3920&rft_dat=%3Cjstor_proqu%3E39168%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201417561&rft_id=info:pmid/8632990&rft_jstor_id=39168&rfr_iscdi=true |