Fast screening of protein surfaces using geometric invariant fingerprints

We develop a rapid and efficient method for the comparison of protein local surface similarities using geometric invariants (fingerprints). By combining fast fingerprint comparison with explicit alignment, we successfully screen the entire Protein Data Bank for proteins that possess local surface si...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-09, Vol.106 (39), p.16622-16626
Hauptverfasser:	Yin, Shuangye, Proctor, Elizabeth A, Lugovskoy, Alexey A, Dokholyan, Nikolay V
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Biological Sciences Curvature Databases, Protein Geometric shapes Geometry Keyword searching Mathematical surfaces Models, Molecular Molecular structure Online searching Protein Conformation Protein folding Protein Interaction Domains and Motifs Proteins Proteins - chemistry Similarity theorem Structural Homology, Protein Surface areas Surface Properties Vertices
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