Characterization of the pre-force-generation state in the actomyosin cross-bridge cycle

Myosin is an actin-based motor protein that generates force by cycling between actin-attached (strong binding: ADP or rigor) and actin-detached (weak binding: ATP or ADP·Pi) states during its ATPase cycle. However, it remains unclear what specific conformational changes in the actin binding site tak...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-06, Vol.105 (25), p.8631-8636
Hauptverfasser:	Sun, Mingxuan, Rose, Michael B, Ananthanarayanan, Shobana K, Jacobs, Donald J, Yengo, Christopher M
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Actomyosin - chemistry Adenosine triphosphatase Adenosine triphosphatases Binding Sites Biochemistry Biological Sciences Biophysics Conformity Energy efficiency Energy transfer Fluorescence Fluorescence Resonance Energy Transfer Kinetics Models, Molecular Nucleotides Phosphates Protein Conformation Proteins Structure-Activity Relationship Temperature
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