Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which

Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which

Jaagsiekte sheep retrovirus (JSRV) can induce rapid, multifocal lung cancer, but JSRV is a simple retrovirus having no known oncogenes. Here we show that the envelope (env) gene of JSRV has the unusual property that it can induce transformation in rat fibroblasts, and thus is likely to be responsibl...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2001-04, Vol.98 (8), p.4443
Hauptverfasser: Rai, Sharath K, Fuh-Mei Duh, Vigdorovich, Vladimir, Danilkovitch-Miagkova, Alla
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Genes
Lung cancer
Proteins
Rodents
Tumors
Viruses
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container_title Proceedings of the National Academy of Sciences - PNAS
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creator Rai, Sharath K
Fuh-Mei Duh
Vigdorovich, Vladimir
Danilkovitch-Miagkova, Alla
description Jaagsiekte sheep retrovirus (JSRV) can induce rapid, multifocal lung cancer, but JSRV is a simple retrovirus having no known oncogenes. Here we show that the envelope (env) gene of JSRV has the unusual property that it can induce transformation in rat fibroblasts, and thus is likely to be responsible for oncogenesis in animals.
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subjects Genes
Lung cancer
Proteins
Rodents
Tumors
Viruses
title Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which
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