Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins

Ricin A-chain (RTA) and saporin-L1 (SAP) catalyze adenosine depurination of 28S rRNA to inhibit protein synthesis and cause cell death. We present the crystal structures of RTA and SAP in complex with transition state analogue inhibitors. These tight-binding inhibitors mimic the sarcin-ricin recogni...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (48), p.20276-20281
Hauptverfasser:	Ho, Meng-Chiao, Sturm, Matthew B, Almo, Steven C, Schramm, Vern L
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites ADENINES ADENOSINE Amides ARGININE Arginine - chemistry Binding sites Biological Sciences CATALYSIS Chemical bases CRYSTAL STRUCTURE Crystallization DEATH DNA Electron density GEOMETRY GUANINE Hydrogen bonds Immunotoxins MATERIALS SCIENCE Models, Molecular Molecular Structure POLARIZATION Protein synthesis PROTEINS Purines - chemistry Ribonucleic acid Ribosome Inactivating Proteins - chemistry Ribosome Inactivating Proteins, Type 1 - chemistry Ribosomes Ricin - chemistry RNA STABILIZATION SYNTHESIS
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!