Quantification of the effect of vaccination on transmission of avian influenza (H7N7) in chickens
Recent outbreaks of highly pathogenic avian influenza (HPAI) viruses in poultry and their threatening zoonotic consequences emphasize the need for effective control measures. Although vaccination of poultry against avian influenza provides a potentially attractive control measure, little is known ab...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2005-12, Vol.102 (50), p.18141-18146 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Goot, J.A. van der Koch, G Jong, M.C.M. de Boven, M. van |
| description | Recent outbreaks of highly pathogenic avian influenza (HPAI) viruses in poultry and their threatening zoonotic consequences emphasize the need for effective control measures. Although vaccination of poultry against avian influenza provides a potentially attractive control measure, little is known about the effect of vaccination on epidemiologically relevant parameters, such as transmissibility and the infectious period. We used transmission experiments to study the effect of vaccination on the transmission characteristics of HPAI A/Chicken/Netherlands/03 H7N7 in chickens. In the experiments, a number of infected and uninfected chickens is housed together and the infection chain is monitored by virus isolation and serology. Analysis is based on a stochastic susceptible, latently infected, infectious, recovered (SEIR) epidemic model. We found that vaccination is able to reduce the transmission level to such an extent that a major outbreak is prevented, important variables being the type of vaccine (H7N1 or H7N3) and the moment of challenge after vaccination. Two weeks after vaccination, both vaccines completely block transmission. One week after vaccination, the H7N1 vaccine is better than the H7N3 vaccine at reducing the spread of the H7N7 virus. We discuss the implications of these findings for the use of vaccination programs in poultry and the value of transmission experiments in the process of choosing vaccine. |
| doi_str_mv | 10.1073/pnas.0505098102 |
| format | Article |
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Although vaccination of poultry against avian influenza provides a potentially attractive control measure, little is known about the effect of vaccination on epidemiologically relevant parameters, such as transmissibility and the infectious period. We used transmission experiments to study the effect of vaccination on the transmission characteristics of HPAI A/Chicken/Netherlands/03 H7N7 in chickens. In the experiments, a number of infected and uninfected chickens is housed together and the infection chain is monitored by virus isolation and serology. Analysis is based on a stochastic susceptible, latently infected, infectious, recovered (SEIR) epidemic model. We found that vaccination is able to reduce the transmission level to such an extent that a major outbreak is prevented, important variables being the type of vaccine (H7N1 or H7N3) and the moment of challenge after vaccination. Two weeks after vaccination, both vaccines completely block transmission. One week after vaccination, the H7N1 vaccine is better than the H7N3 vaccine at reducing the spread of the H7N7 virus. We discuss the implications of these findings for the use of vaccination programs in poultry and the value of transmission experiments in the process of choosing vaccine.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0505098102</identifier><identifier>PMID: 16330777</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Animals ; Antibodies, Viral - blood ; avian influenza ; Avian influenza virus ; Biological Sciences ; Chickens ; disease ; disease control ; Disease outbreaks ; Disease Outbreaks - prevention & control ; Disease Outbreaks - veterinary ; Disease transmission ; Dosage ; efficacy ; epidemic ; epidemiology ; Evaluation Studies as Topic ; Experimental infection ; flocks ; H7N3 subtype influenza A virus ; Hemagglutinins - genetics ; immunization ; Infections ; Influenza ; Influenza A virus ; Influenza A Virus, H7N7 Subtype - genetics ; Influenza in Birds - immunology ; Influenza in Birds - prevention & control ; Influenza in Birds - transmission ; mathematical models ; Microbiology ; Models, Biological ; Poultry ; Poultry Diseases - epidemiology ; Poultry Diseases - virology ; protein ; SEIR model ; Sequence Analysis, DNA - veterinary ; turkeys ; Vaccination ; Vaccination - veterinary ; Vaccines ; virus ; Viruses</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2005-12, Vol.102 (50), p.18141-18146</ispartof><rights>Copyright 2005 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Dec 13, 2005</rights><rights>Copyright © 2005, The National Academy of Sciences 2005</rights><rights>Wageningen University & Research</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-2de21b7d1c2289a762f6870865232281a354c67a397dff2cd9699766b40d90ef3</citedby><cites>FETCH-LOGICAL-c604t-2de21b7d1c2289a762f6870865232281a354c67a397dff2cd9699766b40d90ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/102/50.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4152741$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4152741$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16330777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goot, J.A. van der</creatorcontrib><creatorcontrib>Koch, G</creatorcontrib><creatorcontrib>Jong, M.C.M. de</creatorcontrib><creatorcontrib>Boven, M. van</creatorcontrib><title>Quantification of the effect of vaccination on transmission of avian influenza (H7N7) in chickens</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Recent outbreaks of highly pathogenic avian influenza (HPAI) viruses in poultry and their threatening zoonotic consequences emphasize the need for effective control measures. Although vaccination of poultry against avian influenza provides a potentially attractive control measure, little is known about the effect of vaccination on epidemiologically relevant parameters, such as transmissibility and the infectious period. We used transmission experiments to study the effect of vaccination on the transmission characteristics of HPAI A/Chicken/Netherlands/03 H7N7 in chickens. In the experiments, a number of infected and uninfected chickens is housed together and the infection chain is monitored by virus isolation and serology. Analysis is based on a stochastic susceptible, latently infected, infectious, recovered (SEIR) epidemic model. We found that vaccination is able to reduce the transmission level to such an extent that a major outbreak is prevented, important variables being the type of vaccine (H7N1 or H7N3) and the moment of challenge after vaccination. Two weeks after vaccination, both vaccines completely block transmission. One week after vaccination, the H7N1 vaccine is better than the H7N3 vaccine at reducing the spread of the H7N7 virus. We discuss the implications of these findings for the use of vaccination programs in poultry and the value of transmission experiments in the process of choosing vaccine.</description><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>avian influenza</subject><subject>Avian influenza virus</subject><subject>Biological Sciences</subject><subject>Chickens</subject><subject>disease</subject><subject>disease control</subject><subject>Disease outbreaks</subject><subject>Disease Outbreaks - prevention & control</subject><subject>Disease Outbreaks - veterinary</subject><subject>Disease transmission</subject><subject>Dosage</subject><subject>efficacy</subject><subject>epidemic</subject><subject>epidemiology</subject><subject>Evaluation Studies as Topic</subject><subject>Experimental infection</subject><subject>flocks</subject><subject>H7N3 subtype influenza A virus</subject><subject>Hemagglutinins - genetics</subject><subject>immunization</subject><subject>Infections</subject><subject>Influenza</subject><subject>Influenza A virus</subject><subject>Influenza A Virus, H7N7 Subtype - genetics</subject><subject>Influenza in Birds - immunology</subject><subject>Influenza in Birds - prevention & control</subject><subject>Influenza in Birds - transmission</subject><subject>mathematical models</subject><subject>Microbiology</subject><subject>Models, Biological</subject><subject>Poultry</subject><subject>Poultry Diseases - epidemiology</subject><subject>Poultry Diseases - virology</subject><subject>protein</subject><subject>SEIR model</subject><subject>Sequence Analysis, DNA - veterinary</subject><subject>turkeys</subject><subject>Vaccination</subject><subject>Vaccination - veterinary</subject><subject>Vaccines</subject><subject>virus</subject><subject>Viruses</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktv1DAUhSMEokNhzQZBxALRRdrrR_xggYQqoEgVCEHXlsexZzxknMFOpsCvxyFRB9hUkWzl3u-c-DqnKB4jOEXAydku6HQKdX6kQIDvFAsEElWMSrhbLAAwrwTF9Kh4kNIGAGQt4H5xhBghwDlfFPrzoEPvnTe6910oO1f2a1ta56zpx7e9NsaHuRnKPuqQtj6lGdZ7r0Ppg2sHG37p8uUF_8hPcqE0a2--2ZAeFvecbpN9NO_HxdW7t1_PL6rLT-8_nL-5rAwD2le4sRgteYMMxkJqzrBjgoNgNSa5gjSpqWFcE8kb57BpJJOSM7ak0EiwjhwXrybfa72ywYe8qKCj8Ul12qvWL6OOP9X1EFVox203LJMilFCOs_j1JM7FrW2MDXnQVu2i346i0eDfTvBrter2ChGECSfZ4MVsELvvg029ypdkbNvqYLshKSaEZIKyW0HEKRGk5hl8_h-46YYY8hUqDIgCRWT87NkEmdilFK27OTICNSZEjQlRh4RkxdO_Jz3wcyQycDIDo_Jgh1WdLQWiSLmhbXv7o89seQubkScTskl9F28YimrM_7SfTW2nO6VXMf-tqy95PgIIWA4GI78Bk17jJw</recordid><startdate>20051213</startdate><enddate>20051213</enddate><creator>Goot, J.A. van der</creator><creator>Koch, G</creator><creator>Jong, M.C.M. de</creator><creator>Boven, M. van</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>QVL</scope></search><sort><creationdate>20051213</creationdate><title>Quantification of the effect of vaccination on transmission of avian influenza (H7N7) in chickens</title><author>Goot, J.A. van der ; Koch, G ; Jong, M.C.M. de ; Boven, M. van</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c604t-2de21b7d1c2289a762f6870865232281a354c67a397dff2cd9699766b40d90ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>avian influenza</topic><topic>Avian influenza virus</topic><topic>Biological Sciences</topic><topic>Chickens</topic><topic>disease</topic><topic>disease control</topic><topic>Disease outbreaks</topic><topic>Disease Outbreaks - prevention & control</topic><topic>Disease Outbreaks - veterinary</topic><topic>Disease transmission</topic><topic>Dosage</topic><topic>efficacy</topic><topic>epidemic</topic><topic>epidemiology</topic><topic>Evaluation Studies as Topic</topic><topic>Experimental infection</topic><topic>flocks</topic><topic>H7N3 subtype influenza A virus</topic><topic>Hemagglutinins - genetics</topic><topic>immunization</topic><topic>Infections</topic><topic>Influenza</topic><topic>Influenza A virus</topic><topic>Influenza A Virus, H7N7 Subtype - genetics</topic><topic>Influenza in Birds - immunology</topic><topic>Influenza in Birds - prevention & control</topic><topic>Influenza in Birds - transmission</topic><topic>mathematical models</topic><topic>Microbiology</topic><topic>Models, Biological</topic><topic>Poultry</topic><topic>Poultry Diseases - epidemiology</topic><topic>Poultry Diseases - virology</topic><topic>protein</topic><topic>SEIR model</topic><topic>Sequence Analysis, DNA - veterinary</topic><topic>turkeys</topic><topic>Vaccination</topic><topic>Vaccination - veterinary</topic><topic>Vaccines</topic><topic>virus</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goot, J.A. van der</creatorcontrib><creatorcontrib>Koch, G</creatorcontrib><creatorcontrib>Jong, M.C.M. de</creatorcontrib><creatorcontrib>Boven, M. van</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>NARCIS:Publications</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goot, J.A. van der</au><au>Koch, G</au><au>Jong, M.C.M. de</au><au>Boven, M. van</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantification of the effect of vaccination on transmission of avian influenza (H7N7) in chickens</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2005-12-13</date><risdate>2005</risdate><volume>102</volume><issue>50</issue><spage>18141</spage><epage>18146</epage><pages>18141-18146</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Recent outbreaks of highly pathogenic avian influenza (HPAI) viruses in poultry and their threatening zoonotic consequences emphasize the need for effective control measures. Although vaccination of poultry against avian influenza provides a potentially attractive control measure, little is known about the effect of vaccination on epidemiologically relevant parameters, such as transmissibility and the infectious period. We used transmission experiments to study the effect of vaccination on the transmission characteristics of HPAI A/Chicken/Netherlands/03 H7N7 in chickens. In the experiments, a number of infected and uninfected chickens is housed together and the infection chain is monitored by virus isolation and serology. Analysis is based on a stochastic susceptible, latently infected, infectious, recovered (SEIR) epidemic model. We found that vaccination is able to reduce the transmission level to such an extent that a major outbreak is prevented, important variables being the type of vaccine (H7N1 or H7N3) and the moment of challenge after vaccination. Two weeks after vaccination, both vaccines completely block transmission. One week after vaccination, the H7N1 vaccine is better than the H7N3 vaccine at reducing the spread of the H7N7 virus. We discuss the implications of these findings for the use of vaccination programs in poultry and the value of transmission experiments in the process of choosing vaccine.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>16330777</pmid><doi>10.1073/pnas.0505098102</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibodies, Viral - blood avian influenza Avian influenza virus Biological Sciences Chickens disease disease control Disease outbreaks Disease Outbreaks - prevention & control Disease Outbreaks - veterinary Disease transmission Dosage efficacy epidemic epidemiology Evaluation Studies as Topic Experimental infection flocks H7N3 subtype influenza A virus Hemagglutinins - genetics immunization Infections Influenza Influenza A virus Influenza A Virus, H7N7 Subtype - genetics Influenza in Birds - immunology Influenza in Birds - prevention & control Influenza in Birds - transmission mathematical models Microbiology Models, Biological Poultry Poultry Diseases - epidemiology Poultry Diseases - virology protein SEIR model Sequence Analysis, DNA - veterinary turkeys Vaccination Vaccination - veterinary Vaccines virus Viruses |
| title | Quantification of the effect of vaccination on transmission of avian influenza (H7N7) in chickens |
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