Superoxide dismutase 1 (SOD1) is essential for H^sub 2^O^sub 2^-mediated oxidation and inactivation of phosphatases in growth factor signaling

Superoxide dismutase 1 (SOD1) is an abundant copper/zinc enzyme found in the cytoplasm that converts superoxide into hydrogen peroxide and molecular oxygen. Tetrathiomolybdate (ATN-224) has been recently identified as an inhibitor of SOD1 that attenuates FGF-2- and VEGF-mediated phosphorylation of E...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-05, Vol.105 (20), p.7147
Hauptverfasser:	Juarez, Jose C, Manuia, Mari, Burnett, Mark E, Betancourt, Oscar, Boivin, Benoit, Shaw, David E, Tonks, Nicholas K, Mazar, Andrew P, Doñate, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Copper Enzymes Oxidation Proteins Zinc
Online-Zugang:	Volltext
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