Natural Killer Cells in HIV-1 Infection: Dichotomous Effects of Viremia on Inhibitory and Activating Receptors and Their Functional Correlates

Natural killer (NK) cells play a central role in host defense against various pathogens. Functional defects of NK cells in HIV-1 infection as a direct effect of abnormal expression or function of inhibitory NK receptors (iNKRs), activating natural cytotoxicity receptors (NCRs), and NKG2D have not ye...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-12, Vol.100 (25), p.15011-15016
Hauptverfasser:	Mavilio, Domenico, Benjamin, Janet, Daucher, Marybeth, Lombardo, Gabriella, Kottilil, Shyam, Planta, Marie A., Marcenaro, Emanuela, Bottino, Cristina, Moretta, Lorenzo, Moretta, Alessandro, Fauci, Anthony S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Biological Sciences CD16 antigen CD56 antigen CD56 Antigen - biosynthesis Cell lines Cultured cells Cytotoxicity Down-Regulation Flow Cytometry Highly active antiretroviral therapy HIV HIV 1 HIV Infections HIV-1 - metabolism Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immunology Infections Interferon-gamma - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - virology Leukocytes, Mononuclear - metabolism natural cytotoxicity receptors natural killer cell receptors Natural killer cells Phenotype Phenotypes Polymerase Chain Reaction Receptors Receptors, IgG - biosynthesis Reverse Transcriptase Polymerase Chain Reaction Transforming Growth Factor beta - metabolism Viremia
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