Tapasin Enhances MHC Class I Peptide Presentation According to Peptide Half-Life

Understanding how peptides are selected for presentation by MHC class I is crucial to vaccination strategies based on cytotoxic T lymphocyte priming. We have studied this selection of the MHC class I peptide repertoire in terms of the presentation of a series of individual peptides with a wide range...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-08, Vol.101 (32), p.11737-11742
Hauptverfasser:	Howarth, Mark, Williams, Anthony, Tolstrup, Anne B., Elliott, Tim, Nathenson, Stanley G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies Antibodies - immunology Antigen Presentation Antiporters - physiology Biological Sciences Calreticulin - physiology Cell Line Cell lines Cytometry Disulfides Fibroblasts Half lives Half-Life Heat-Shock Proteins - physiology Histocompatibility Antigens Class I - immunology Humans Immunity Immunoglobulins - physiology Immunology Isomerases - physiology Membrane Transport Proteins Mice Mice, Knockout Molecules Peptides Peptides - immunology Protein Disulfide-Isomerases T lymphocytes
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