helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis

Translational control plays an important role in cell growth and tumorigenesis. Cap-dependent translation initiation of mammalian mRNAs with structured 5'UTRs requires the DExH-box protein, DHX29, in vitro. Here we show that DHX29 is important for translation in vivo. Down-regulation of DHX29 l...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (52), p.22217-22222
Hauptverfasser:	Parsyan, Armen, Shahbazian, David, Martineau, Yvan, Petroulakis, Emmanuel, Alain, Tommy, Larsson, Ola, Mathonnet, Geraldine, Tettweiler, Gritta, Hellen, Christopher U, Pestova, Tatyana V, Svitkin, Yuri V, Sonenberg, Nahum
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions Animals Biological Sciences Cancer Cell culture Cell growth Cell lines Cell Proliferation Down-Regulation Five prime untranslated regions HeLa Cells Humans Mammals Messenger RNA Mice Mice, Nude Neoplasm Transplantation Neoplasms - enzymology Neoplasms - etiology Neoplasms - genetics Neoplasms - pathology Peptide Chain Initiation, Translational - physiology Peptide initiation factors Polyribosomes Proteins Ribosome Subunits, Small, Eukaryotic - metabolism Ribosomes RNA Helicases - antagonists & inhibitors RNA Helicases - genetics RNA Helicases - metabolism RNA Interference RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics Small interfering RNA Transplantation, Heterologous Tumors
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