Modeling oncogene addiction using RNA interference

The clinical efficacy of selective kinase inhibitors suggests that some cancer cells may become dependent on a single oncogene for survival. RNAi has been increasingly used to understand such "oncogene addiction" and validate new therapeutic targets. However, RNAi approaches suffer from si...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-08, Vol.105 (34), p.12480-12484
Hauptverfasser:	Rothenberg, S. Michael, Engelman, Jeffrey A, Le, Sheila, Riese, David J. II, Haber, Daniel A, Settleman, Jeffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Addiction Antibodies Biological Sciences Cancer Cell death Cell Line, Tumor Cell lines Cells Genetic mutation Growth factor receptors Humans Kinases Lung cancer Lung neoplasms Lung Neoplasms - genetics Lung Neoplasms - pathology Models, Biological Mutation Oncogenes Oncogenes - genetics Oncogenes - physiology Oncology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Receptor, ErbB-3 Ribonucleic acid RNA RNA Interference RNA, Small Interfering - pharmacology Viruses
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