Positive Inotropic and Lusitropic Effects of HNO/NO-in Failing Hearts: Independence from β-Adrenergic Signaling

Nitroxyl anion (HNO/NO-), the one-electron reduced form of nitric oxide (NO), induces positive cardiac inotropy and selective venodilation in the normal in vivo circulation. Here we tested whether HNO/NO-augments systolic and diastolic function of failing hearts, and whether contrary to NO/nitrates...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-04, Vol.100 (9), p.5537-5542
Hauptverfasser:	Paolocci, Nazareno, Katori, Tatsuo, Champion, Hunter C., St. John, Marcus E., Miranda, Katrina M., Fukuto, Jon M., Wink, David A., Kass, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Animals Biological Sciences Blood plasma Calcitonin Gene-Related Peptide - blood Calcium Cell division Congestive heart failure Coronary sinus Cyclic GMP - blood Dogs Drug interactions Electrons Heart Heart failure Heart Failure - drug therapy Heart Failure - physiopathology Hemodynamics Myocardial Contraction - drug effects Nitrates Nitric oxide Nitrogen Oxides - pharmacology Nitrogen Oxides - therapeutic use Pharmacology Receptors, Adrenergic, beta - metabolism Signal Transduction Vasodilation
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