A Cofactor Approach to Copper-Dependent Catalytic Antibodies

A strategy for the preparation of semisynthetic copper(II)-based catalytic metalloproteins is described in which a metal-binding bis-imidazole cofactor is incorporated into the combining site of the aldolase antibody 38C2. Antibody 38C2 features a large hydrophobic-combining site pocket with a highl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-03, Vol.99 (5), p.2648-2653
Hauptverfasser:	Nicholas, Kenneth M., Wentworth, Paul, Harwig, Curtis W., Wentworth, Anita D., Shafton, Asher, Janda, Kim D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anhydrides Anhydrides - chemistry Antibodies Antibodies, Catalytic - chemistry Antibodies, Monoclonal - chemistry Biochemistry Biological Sciences Catalysts Copper Copper - chemistry Enzymes Esters Fructose-Bisphosphate Aldolase - chemistry Hydrolysis Imidazoles - chemistry Immunoglobulin Fab Fragments - chemistry Ketones - chemistry Kinetics Lactones Lactones - chemistry Ligands Molecular Structure Proteins Room temperature
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