Loss of Perivascular Aquaporin 4 May Underlie Deficient Water and K+Homeostasis in the Human Epileptogenic Hippocampus

An abnormal accumulation of extracellular K+in the brain has been implicated in the generation of seizures in patients with mesial temporal lobe epilepsy (MTLE) and hippocampal sclerosis. Experimental studies have shown that clearance of extracellular K+is compromised by removal of the perivascular...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-01, Vol.102 (4), p.1193-1198
Hauptverfasser:	Eid, Tore, Lee, Tih-Shih W., Thomas, Marion J., Amiry-Moghaddam, Mahmood, Bjørnsen, Lars P., Spencer, Dennis D., Agre, Peter, Ottersen, Ole P., de Lanerolle, Nihal C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Amino Acid Sequence Antibodies Aquaporin 4 Aquaporins - analysis Astrocytes Astrocytes - chemistry Biological Sciences Body Water - metabolism Brain research Carbohydrates Cell membranes Child Convulsions & seizures Epilepsy Epilepsy, Temporal Lobe - metabolism Female Hippocampus Hippocampus - chemistry Hippocampus - metabolism Homeostasis Humans Immunohistochemistry Male Membranes Middle Aged Molecular Sequence Data Neuropil Neuroscience P branes Potassium Potassium - metabolism Sclerosis Seizures Temporal lobe epilepsy Water
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