A Mutant Cholera Toxin B Subunit That Binds GM1-Ganglioside but Lacks Immunomodulatory or Toxic Activity

GM1-ganglioside receptor binding by the B subunit of cholera toxin (CtxB) is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin A subunit into cells. More recently, GM1 binding by isolated CtxB, or the related B subunit of Escherichia coli heat-labile enterotoxin...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-07, Vol.98 (15), p.8536-8541
Hauptverfasser:	Aman, A T, Fraser, S, Merritt, E A, Rodigherio, C, Kenny, M, Ahn, M, Hol, W G, Williams, N A, Lencer, W I, Hirst, T R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - metabolism Adjuvants, Immunologic - toxicity Alanine - genetics Animals Apoptosis B lymphocytes Bacteria Biochemistry Biological Sciences Cells Cells, Cultured Cholera cholera toxin Cholera Toxin - chemistry Cholera Toxin - genetics Cholera Toxin - metabolism Cholera Toxin - toxicity Crystallography, X-Ray Cultured cells Cytometry G(M1) Ganglioside - metabolism ganglioside GM1 Isoleucine - genetics Mice Models, Molecular Molecules Mutagenesis, Site-Directed Mutation Poisons Protein Structure, Secondary Receptors T lymphocytes Toxins Valine - genetics Vibrio cholerae
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