Mapping Strain Exerted on Blood Vessel Walls Using Deuterium Double-Quantum-Filtered MRI
A technique is described for displaying distinct tissue layers of large blood vessel walls as well as measuring their mechanical strain. The technique is based on deuterium double-quantum-filtered (DQF) spectroscopic imaging. The effectiveness of the double-quantum filtration in suppressing the sign...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1998-04, Vol.95 (8), p.4108-4112 |
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| creator | Sharf, Yehuda Seo, Yoshiteru Eliav, Uzi Akselrod, Solang Navon, Gil |
| description | A technique is described for displaying distinct tissue layers of large blood vessel walls as well as measuring their mechanical strain. The technique is based on deuterium double-quantum-filtered (DQF) spectroscopic imaging. The effectiveness of the double-quantum filtration in suppressing the signal of bulk water is demonstrated on a phantom consisting of rat tail tendon fibers. Only intrafibrillar water is displayed, excluding all other signals of water molecules that reorient isotropically. One- and two-dimensional spectroscopic imaging of bovine aorta and coronary arteries show the characteristic DQF spectrum of each of the tissue layers. This property is used to obtain separate images of the outer layer, the tunica adventitia, or the intermediate layer, the tunica media, or both. To visualize the effect of elongation, the average residual quadrupole splitting is calculated for each pixel. Two-dimensional deuterium quadrupolar splitting images are obtained for a fully relaxed and a 55% elongated sample of bovine coronary artery. These images indicate that the strong effect of strain is associated with water molecules in the tunica adventitia whereas the DQF NMR signal of water in the tunica media is apparently strain-insensitive. After appropriate calibration, these average quadrupolar splitting images can be interpreted as strain maps. |
| doi_str_mv | 10.1073/pnas.95.8.4108 |
| format | Article |
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The technique is based on deuterium double-quantum-filtered (DQF) spectroscopic imaging. The effectiveness of the double-quantum filtration in suppressing the signal of bulk water is demonstrated on a phantom consisting of rat tail tendon fibers. Only intrafibrillar water is displayed, excluding all other signals of water molecules that reorient isotropically. One- and two-dimensional spectroscopic imaging of bovine aorta and coronary arteries show the characteristic DQF spectrum of each of the tissue layers. This property is used to obtain separate images of the outer layer, the tunica adventitia, or the intermediate layer, the tunica media, or both. To visualize the effect of elongation, the average residual quadrupole splitting <Δ νq> is calculated for each pixel. Two-dimensional deuterium quadrupolar splitting images are obtained for a fully relaxed and a 55% elongated sample of bovine coronary artery. These images indicate that the strong effect of strain is associated with water molecules in the tunica adventitia whereas the DQF NMR signal of water in the tunica media is apparently strain-insensitive. After appropriate calibration, these average quadrupolar splitting images can be interpreted as strain maps.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.95.8.4108</identifier><identifier>PMID: 9539698</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Aorta ; Aorta - physiology ; Arteries ; Biochemistry ; Blood vessels ; Cattle ; Coronary vessels ; Coronary Vessels - physiology ; Deuterium ; In Vitro Techniques ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Spectroscopy ; Molecules ; Muscle, Smooth, Vascular - physiology ; NMR ; Nuclear magnetic resonance ; Phantoms, Imaging ; Physical Sciences ; Rats ; Rats, Wistar ; Sensitivity and Specificity ; Spectroscopy ; Stress, Mechanical ; Tendons ; Tendons - physiology ; Tunica Media - physiology ; Ungulates</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1998-04, Vol.95 (8), p.4108-4112</ispartof><rights>Copyright 1993-1998 National Academy of Sciences</rights><rights>Copyright National Academy of Sciences Apr 14, 1998</rights><rights>Copyright © 1998, The National Academy of Sciences 1998</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-6d376919e6ff636c3e5127ba06a007f8dc6cfc345e8dac3d5767cb6436aa04d83</citedby><cites>FETCH-LOGICAL-c482t-6d376919e6ff636c3e5127ba06a007f8dc6cfc345e8dac3d5767cb6436aa04d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/95/8.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/44857$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/44857$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27922,27923,53789,53791,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9539698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharf, Yehuda</creatorcontrib><creatorcontrib>Seo, Yoshiteru</creatorcontrib><creatorcontrib>Eliav, Uzi</creatorcontrib><creatorcontrib>Akselrod, Solang</creatorcontrib><creatorcontrib>Navon, Gil</creatorcontrib><title>Mapping Strain Exerted on Blood Vessel Walls Using Deuterium Double-Quantum-Filtered MRI</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>A technique is described for displaying distinct tissue layers of large blood vessel walls as well as measuring their mechanical strain. The technique is based on deuterium double-quantum-filtered (DQF) spectroscopic imaging. The effectiveness of the double-quantum filtration in suppressing the signal of bulk water is demonstrated on a phantom consisting of rat tail tendon fibers. Only intrafibrillar water is displayed, excluding all other signals of water molecules that reorient isotropically. One- and two-dimensional spectroscopic imaging of bovine aorta and coronary arteries show the characteristic DQF spectrum of each of the tissue layers. This property is used to obtain separate images of the outer layer, the tunica adventitia, or the intermediate layer, the tunica media, or both. To visualize the effect of elongation, the average residual quadrupole splitting <Δ νq> is calculated for each pixel. Two-dimensional deuterium quadrupolar splitting images are obtained for a fully relaxed and a 55% elongated sample of bovine coronary artery. These images indicate that the strong effect of strain is associated with water molecules in the tunica adventitia whereas the DQF NMR signal of water in the tunica media is apparently strain-insensitive. 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Seo, Yoshiteru ; Eliav, Uzi ; Akselrod, Solang ; Navon, Gil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-6d376919e6ff636c3e5127ba06a007f8dc6cfc345e8dac3d5767cb6436aa04d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Aorta - physiology</topic><topic>Arteries</topic><topic>Biochemistry</topic><topic>Blood vessels</topic><topic>Cattle</topic><topic>Coronary vessels</topic><topic>Coronary Vessels - physiology</topic><topic>Deuterium</topic><topic>In Vitro Techniques</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Molecules</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Phantoms, Imaging</topic><topic>Physical Sciences</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sensitivity and Specificity</topic><topic>Spectroscopy</topic><topic>Stress, Mechanical</topic><topic>Tendons</topic><topic>Tendons - physiology</topic><topic>Tunica Media - physiology</topic><topic>Ungulates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharf, Yehuda</creatorcontrib><creatorcontrib>Seo, Yoshiteru</creatorcontrib><creatorcontrib>Eliav, Uzi</creatorcontrib><creatorcontrib>Akselrod, Solang</creatorcontrib><creatorcontrib>Navon, Gil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharf, Yehuda</au><au>Seo, Yoshiteru</au><au>Eliav, Uzi</au><au>Akselrod, Solang</au><au>Navon, Gil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mapping Strain Exerted on Blood Vessel Walls Using Deuterium Double-Quantum-Filtered MRI</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1998-04-14</date><risdate>1998</risdate><volume>95</volume><issue>8</issue><spage>4108</spage><epage>4112</epage><pages>4108-4112</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>A technique is described for displaying distinct tissue layers of large blood vessel walls as well as measuring their mechanical strain. 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These images indicate that the strong effect of strain is associated with water molecules in the tunica adventitia whereas the DQF NMR signal of water in the tunica media is apparently strain-insensitive. After appropriate calibration, these average quadrupolar splitting images can be interpreted as strain maps.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>9539698</pmid><doi>10.1073/pnas.95.8.4108</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1998-04, Vol.95 (8), p.4108-4112 |
| issn | 0027-8424 1091-6490 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Aorta Aorta - physiology Arteries Biochemistry Blood vessels Cattle Coronary vessels Coronary Vessels - physiology Deuterium In Vitro Techniques Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy Molecules Muscle, Smooth, Vascular - physiology NMR Nuclear magnetic resonance Phantoms, Imaging Physical Sciences Rats Rats, Wistar Sensitivity and Specificity Spectroscopy Stress, Mechanical Tendons Tendons - physiology Tunica Media - physiology Ungulates |
| title | Mapping Strain Exerted on Blood Vessel Walls Using Deuterium Double-Quantum-Filtered MRI |
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