Mapping the Early Steps in the pH-Induced Conformational Conversion of the Prion Protein

Under certain conditions, the prion protein (PrP) undergoes a conformational change from the normal cellular isoform, PrPC, to PrPSc, an infectious isoform capable of causing neurodegenerative diseases in many mammals. Conversion can be triggered by low pH, and in vivo this appears to take place in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-03, Vol.98 (6), p.2985-2989
Hauptverfasser:	Darwin O. V. Alonso, DeArmond, Stephen J., Cohen, Fred E., Daggett, Valerie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological Sciences Central nervous system diseases Creutzfeldt Jakob syndrome Cricetinae Humans Hydrogen-Ion Concentration Mesocricetus Models, Molecular Molecular dynamics Molecules Neurodegenerative diseases Nuclear Magnetic Resonance, Biomolecular - methods Peptide Mapping Phosphorus Prion diseases Prions Prions - chemistry Protein isoforms Protein Structure, Tertiary Proteins PrPC protein PrPC Proteins - chemistry PrPSc protein PrPSc Proteins - chemistry
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