NF-kappaB-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection

NF-kappaB-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection

The possibility that bacteria may have evolved strategies to overcome host cell apoptosis was explored by using Rickettsia rickettsii, an obligate intracellular Gram-negative bacteria that is the etiologic agent of Rocky Mountain spotted fever. The vascular endothelial cell, the primary target cell...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1998-04, Vol.95 (8), p.4646
Hauptverfasser: Clifton, Dawn R, Goss, Rachel A, Sahni, Sanjeev K, van Antwerp, Daniel
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Sprache:eng
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Bacteria
Infections
Microbiology
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container_title Proceedings of the National Academy of Sciences - PNAS
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creator Clifton, Dawn R
Goss, Rachel A
Sahni, Sanjeev K
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description The possibility that bacteria may have evolved strategies to overcome host cell apoptosis was explored by using Rickettsia rickettsii, an obligate intracellular Gram-negative bacteria that is the etiologic agent of Rocky Mountain spotted fever. The vascular endothelial cell, the primary target cell during in vivo infection, exhibits no evidence of apoptosis during natural infection and is maintained for a sufficient time to allow replication and cell-to-cell spread prior to eventual death due to necrotic damage.
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source JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry
subjects Bacteria
Infections
Microbiology
title NF-kappaB-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection
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