A Cellular Defense Pathway Regulating Transcription through Poly(ADP-ribosyl)ation in Response to DNA Damage

DNA damage is known to trigger key cellular defense pathways such as those involved in DNA repair. Here we provide evidence for a previously unrecognized pathway regulating transcription in response to DNA damage and show that this regulation is mediated by the abundant nuclear enzyme poly(ADP-ribos...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-08, Vol.97 (18), p.9886-9891
Hauptverfasser:	Vispe, S, Yung, T M, Ritchot, J, Serizawa, H, Satoh, M S
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological Sciences Cell Line Cell-Free System Cloning, Molecular Complementary DNA Cystic Fibrosis Transmembrane Conductance Regulator - genetics Deoxyribonucleic acid DNA DNA breaks DNA Damage DNA Repair Enzymes Escherichia coli Gels Gene Expression Regulation HeLa cells Humans Immune system Messenger RNA Plasmids Poly Adenosine Diphosphate Ribose - metabolism Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Recombinant Proteins - metabolism RNA RNA Polymerase II - metabolism Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!