T Cell Receptor (TCR) α/δ Locus Enhancer Identity and Position Are Critical for the Assembly of TCR δ and α Variable Region Genes

T cell receptor (TCR) δ and α variable region genes are assembled from germ-line gene segments located in a single chromosomal locus in which TCRδ segments are situated between TCRα segments. The TCRα enhancer (Eα) located at the 3′ end of the TCRα/δ locus functions over a long chromosomal distance...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-03, Vol.100 (5), p.2598-2603
Hauptverfasser:	Bassing, Craig H., Tillman, Robert E., Woodman, Barbara B., Canty, David, Monroe, Robert J., Sleckman, Barry P., Alt, Frederick W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Biological Sciences Blotting, Southern CD4 Antigens - biosynthesis CD8 Antigens - biosynthesis Cells Cellular biology DNA probes Enhancer Elements, Genetic Flow Cytometry Gene Rearrangement Genes Genes, T-Cell Receptor alpha - physiology Genes, T-Cell Receptor delta - physiology Genetic loci Genetics Homozygote Hybridomas Hybridomas - metabolism Immunology Lymphocytes - immunology Lymphocytes - metabolism Mice Models, Genetic Mutation Plasmids - metabolism Polymerase Chain Reaction Regional identity T cell antigen receptors T lymphocytes T-Lymphocytes - immunology Thymocytes
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