Identification of Macromolecular Complexes in Cryoelectron Tomograms of Phantom Cells

Electron tomograms of intact frozen-hydrated cells are essentially three-dimensional images of the entire proteome of the cell, and they depict the whole network of macromolecular interactions. However, this information is not easily accessible because of the poor signal-to-noise ratio of the tomogr...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-10, Vol.99 (22), p.14153-14158
Hauptverfasser:	Frangakis, Achilleas S., Böhm, Jochen, Förster, Friedrich, Nickell, Stephan, Nicastro, Daniela, Typke, Dieter, Hegerl, Reiner, Baumeister, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Archaeal Proteins - analysis Atoms Biological Sciences Biophysics Cells Chaperonins - analysis Coated Vesicles Correlation coefficients Cross correlation Cryoelectron Microscopy - methods Cysteine Endopeptidases - analysis Electron microscopes Lipids Liposomes - chemistry Macromolecules Molecules Multienzyme Complexes - analysis Multivariate Analysis Nonlinear Dynamics Pixels Prokaryotic cells Proteasome Endopeptidase Complex Radiation counters
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