Peyer's Patches are Required for Oral Tolerance to Proteins

To clarify the role of Peyer's patches in oral tolerance induction, BALB/c mice were treated in utero with lymphotoxin β-receptor Ig fusion protein to generate mice lacking Peyer's patches. When these Peyer's patch-null mice were fed 25 mg of ovalbumin (OVA) before systemic immunizati...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-03, Vol.98 (6), p.3310-3315
Hauptverfasser:	Fujihashi, Kohtaro, Dohi, Taeko, Rennert, Paul D., Yamamoto, Masafumi, Koga, Toshiya, Kiyono, Hiroshi, McGhee, Jerry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals B lymphocytes B-Lymphocytes - immunology Biological Sciences Cytokines Cytokines - biosynthesis Dams Female g-Interferon Haptens Haptens - immunology Immune Tolerance - immunology Immunization Immunology Lymphotoxin beta Receptor Mice Mice, Inbred BALB C Oral administration Ova Ovalbumin - administration & dosage Ovalbumin - blood Ovalbumin - immunology Peyer's Patches - immunology Peyers patches Proteins Receptors, Tumor Necrosis Factor - genetics Receptors, Tumor Necrosis Factor - immunology Rodents T lymphocytes T-Lymphocytes - immunology Th1 Cells - immunology Th2 Cells - immunology Trinitrobenzenesulfonic Acid - immunology
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