T Cell Receptor ζ Reconstitution Fails to Restore Responses of T Cells Rendered Hyporesponsive by Tumor Necrosis Factor α

Expression and function of the antigen T cell receptor (TCR) play a central role in regulating immune responsiveness. Accordingly, targeting the expression of TCRαβ or its associated CD3 subunits profoundly influences T cell development and adaptive immunity. Down-regulation of the invariant TCRζ ch...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-02, Vol.101 (6), p.1696-1701
Hauptverfasser:	Clark, Joanna M., Annenkov, Alexander E., Panesar, Manvinder, Isomäki, Pia, Chernajovsky, Yuti, Cope, Andrew P., McDevitt, Hugh O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cellular biology Cultured cells Down regulation Hybridomas Immunology Ligation Mice Phosphorylation Receptors Receptors, Antigen, T-Cell - immunology Signal Transduction T cell antigen receptors T lymphocytes T-Lymphocytes - immunology Transcriptional regulatory elements Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factors Tumors
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