Excitation-contraction coupling is unaffected by drastic alteration of the sequence surrounding residues L720-L764 of the alpha1S II-III loop

Excitation-contraction coupling is unaffected by drastic alteration of the sequence surrounding residues L720-L764 of the alpha1S II-III loop

To address whether residues 720-765 of the II-III loop are sufficient to enable skeletal-type (Ca2+ entryindependent) EC coupling and retrograde interaction with RyR1, we constructed a green fluorescent protein (GFP)-tagged chimera (GFP-SkLM) having rabbit skeletal (Sk) DHPR sequence except for a II...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2001-05, Vol.98 (10), p.5892
Hauptverfasser: Wilkens, Christina M, Kasielke, Nicole, Flucher, Bernhard E, Beam, Kurt G, Grabner, Manfred
Format: Artikel
Sprache:eng
Schlagworte:
Anatomy & physiology
Proteins
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Zusammenfassung:To address whether residues 720-765 of the II-III loop are sufficient to enable skeletal-type (Ca2+ entryindependent) EC coupling and retrograde interaction with RyR1, we constructed a green fluorescent protein (GFP)-tagged chimera (GFP-SkLM) having rabbit skeletal (Sk) DHPR sequence except for a II-III loop (L) from the DHPR of the house fly, Musca domestica (M).
ISSN:0027-8424
1091-6490