Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants

The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate. Glutamate toxicity was reduced by both cannabidiol, a nonpsychoactive constituent of marijuana, and the psychotropic c...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-07, Vol.95 (14), p.8268
Hauptverfasser:	Hampson, A J, Grimaldi, M, Axelrod, J, Wink, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - pharmacology Brain Cannabidiol - pharmacology Cell Death - drug effects Cells, Cultured Cellular biology Dronabinol - pharmacology Drug Antagonism Glutamic Acid - toxicity Marijuana Neurology Neurons - drug effects Neurons - metabolism Neurons - pathology Oxidative Stress Rats Rats, Wistar Receptors, Cannabinoid Receptors, Drug - agonists Receptors, Drug - metabolism
Online-Zugang:	Volltext
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