Hematopoietic Stem Cells and Lymphoid Progenitors Express Different Ikaros Isoforms, and Ikaros is Localized to Heterochromatin in Immature Lymphocytes

The generation of lymphoid cells in mice depends on the function of the Ikaros protein. Ikaros has been characterized as a lymphoid-restricted, zinc-finger transcription factor that is derived from an alternatively spliced message. Ikaros knockout mice have defects in multiple cell lineages, raising...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-01, Vol.95 (2), p.657-662
Hauptverfasser:	Klug, Christopher A., Morrison, Sean J., Masek, Marilyn, Hahm, Kyungmin, Smale, Stephen T., Weissman, Irving L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biological Sciences Cell Differentiation Cell lines Cell Nucleus - metabolism Cellular biology DNA-Binding Proteins Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Heterochromatin - metabolism Heterochromatin - ultrastructure Ikaros Transcription Factor Immunology Lymphocytes Lymphocytes - cytology Lymphocytes - metabolism Mice Mice, Inbred C57BL Multipotent stem cells Myeloid cells Neutrophils Progenitor cells Protein isoforms Proteins Rodents Stem cells T lymphocytes Transcription Factors - biosynthesis Transcription Factors - genetics
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