HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian Federation
Most HIV-1 tropism studies have involved non-A subtypes. Our aim was to study the prevalence of R5- and non-R5-tropic HIV-1 variants and the tropism occurrence relative to the CD4 counts, treatment experiences, transmission routes and other features of infection in Russia, where subtype A is presuma...
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| creator | Lopatukhin, Alexey Kireev, Dmitry Kuevda, Dmitry Pokrovskaya, Anastasia Tsyganova, Galina Korovina, Galina Pinsker, Alexander Dementeva, Natalia Sizova, Natalia Peksheva, Olga Zaytseva, Natalia Nosov, Nikolai Urazov, Nail Gerasimov, Valery Ermolinskaya, Natalia Gerasimova, Natalia Sandyreva, Tatyana Volova, Ludmila Grezina, Lilia Kolomeets, Anna Sergeeva, Irina Neshumaev, Dmitry Boyko, Anatoly Kotova, Valeria Balakhontseva, Ludmila Kolpakov, Dmitry Shemshura, Andrey Saukhat, Sergey Bukin, Evgeniy Polyakov, Andrey Kaiser, Rolf Shipulin, German Pokrovsky, Vadim |
| description | Most HIV-1 tropism studies have involved non-A subtypes. Our aim was to study the prevalence of R5- and non-R5-tropic HIV-1 variants and the tropism occurrence relative to the CD4 counts, treatment experiences, transmission routes and other features of infection in Russia, where subtype A is presumably predominant. In this multicenter, single-step, cross-sectional, epidemiologic study, 943 HIV-1-infected patients were enrolled at 12 AIDS centers throughout Russia. Viral tropism was determined using a genotype method-based kit. The V3 loop sequences were analyzed using the geno2pheno resource. The tropism was successfully predicted for 823 (87.3%) patients. Frequencies of R5-tropic and non-R5-tropic viruses in successfully analyzed samples were 70.2% (578) and 29.8% (245), respectively. Co-receptor usage correlated significantly only with the treatment experiences (p = 0.018) and CD4 counts (p = 0.004). But there was no dependence of R5/non-R5 co-receptor usage frequencies on presence/absence of a therapy change (p = 0.664) or HIV infection duration (p = 0.458). According to the env sequences, 457 (83.6%) of the samples in study were subtype A and 70 (12.8%) were subtype B. This indicates a stabilizing of immune system and thus little emergence of X4 viruses. We suggest that CCR5-antagonists could be used in both naïve and experienced patients in Russia after determination of HIV tropism. |
| doi_str_mv | 10.1080/2331205X.2017.1311470 |
| format | Article |
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Our aim was to study the prevalence of R5- and non-R5-tropic HIV-1 variants and the tropism occurrence relative to the CD4 counts, treatment experiences, transmission routes and other features of infection in Russia, where subtype A is presumably predominant. In this multicenter, single-step, cross-sectional, epidemiologic study, 943 HIV-1-infected patients were enrolled at 12 AIDS centers throughout Russia. Viral tropism was determined using a genotype method-based kit. The V3 loop sequences were analyzed using the geno2pheno resource. The tropism was successfully predicted for 823 (87.3%) patients. Frequencies of R5-tropic and non-R5-tropic viruses in successfully analyzed samples were 70.2% (578) and 29.8% (245), respectively. Co-receptor usage correlated significantly only with the treatment experiences (p = 0.018) and CD4 counts (p = 0.004). But there was no dependence of R5/non-R5 co-receptor usage frequencies on presence/absence of a therapy change (p = 0.664) or HIV infection duration (p = 0.458). According to the env sequences, 457 (83.6%) of the samples in study were subtype A and 70 (12.8%) were subtype B. This indicates a stabilizing of immune system and thus little emergence of X4 viruses. We suggest that CCR5-antagonists could be used in both naïve and experienced patients in Russia after determination of HIV tropism.</description><identifier>ISSN: 2331-205X</identifier><identifier>EISSN: 2331-205X</identifier><identifier>EISSN: 2770-7571</identifier><identifier>DOI: 10.1080/2331205X.2017.1311470</identifier><language>eng</language><publisher>Abingdon: Cogent</publisher><subject>CCR5 protein ; CD4 antigen ; Epidemiology ; Genotypes ; Genotyping ; HIV ; HIV-1 ; Human immunodeficiency virus ; Immune system ; molecular epidemiology ; receptors, CCR5 ; receptors, CXCR4 ; Russia ; Tropism</subject><ispartof>Cogent medicine, 2017-01, Vol.4 (1), p.1311470</ispartof><rights>2017 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license 2017</rights><rights>2017 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license. 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Our aim was to study the prevalence of R5- and non-R5-tropic HIV-1 variants and the tropism occurrence relative to the CD4 counts, treatment experiences, transmission routes and other features of infection in Russia, where subtype A is presumably predominant. In this multicenter, single-step, cross-sectional, epidemiologic study, 943 HIV-1-infected patients were enrolled at 12 AIDS centers throughout Russia. Viral tropism was determined using a genotype method-based kit. The V3 loop sequences were analyzed using the geno2pheno resource. The tropism was successfully predicted for 823 (87.3%) patients. Frequencies of R5-tropic and non-R5-tropic viruses in successfully analyzed samples were 70.2% (578) and 29.8% (245), respectively. Co-receptor usage correlated significantly only with the treatment experiences (p = 0.018) and CD4 counts (p = 0.004). But there was no dependence of R5/non-R5 co-receptor usage frequencies on presence/absence of a therapy change (p = 0.664) or HIV infection duration (p = 0.458). According to the env sequences, 457 (83.6%) of the samples in study were subtype A and 70 (12.8%) were subtype B. This indicates a stabilizing of immune system and thus little emergence of X4 viruses. We suggest that CCR5-antagonists could be used in both naïve and experienced patients in Russia after determination of HIV tropism.</description><subject>CCR5 protein</subject><subject>CD4 antigen</subject><subject>Epidemiology</subject><subject>Genotypes</subject><subject>Genotyping</subject><subject>HIV</subject><subject>HIV-1</subject><subject>Human immunodeficiency virus</subject><subject>Immune system</subject><subject>molecular epidemiology</subject><subject>receptors, CCR5</subject><subject>receptors, 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| ispartof | Cogent medicine, 2017-01, Vol.4 (1), p.1311470 |
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| source | Taylor & Francis Open Access; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central |
| subjects | CCR5 protein CD4 antigen Epidemiology Genotypes Genotyping HIV HIV-1 Human immunodeficiency virus Immune system molecular epidemiology receptors, CCR5 receptors, CXCR4 Russia Tropism |
| title | HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian Federation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T07%3A53%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=HIV-1%20genotyping%20tropism%20profile%20in%20an%20HIV-positive%20population%20throughout%20the%20Russian%20Federation&rft.jtitle=Cogent%20medicine&rft.au=Lopatukhin,%20Alexey&rft.date=2017-01-01&rft.volume=4&rft.issue=1&rft.spage=1311470&rft.pages=1311470-&rft.issn=2331-205X&rft.eissn=2331-205X&rft_id=info:doi/10.1080/2331205X.2017.1311470&rft_dat=%3Cproquest_infor%3E2013733507%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2013733507&rft_id=info:pmid/&rft_doaj_id=oai_doaj_org_article_9e9f7a09507f4aa5b74b9085266dd1d4&rfr_iscdi=true |