Defective Stratum Corneum and Early Neonatal Death in Mice Lacking the Gene for Transglutaminase 1 (Keratinocyte Transglutaminase)

The stratum corneum of the skin serves as an effective barrier for maintenance of the internal milieu against the external environment. At the cell periphery of the stratum corneum is the cell envelope, a highly insoluble membranous structure composed of precursor proteins crosslinked by ε -(γ -glut...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-02, Vol.95 (3), p.1044-1049
Hauptverfasser:	Matsuki, Masato, Yamashita, Fumiyoshi, Ishida-Yamamoto, Akemi, Yamada, Keiko, Kinoshita, Chikako, Fushiki, Shinji, Ueda, Eiichiro, Morishima, Yohichi, Tabata, Kohichi, Yasuno, Hirokazu, Hashida, Mitsuru, Iizuka, Hajime, Ikawa, Masahito, Okabe, Masaru, Kondoh, Gen, Kinoshita, Taroh, Takeda, Junji, Yamanishi, Kiyofumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Animals Biological Sciences Cell lines Cell membranes Cells Cellular biology Cytoplasm Disease Models, Animal Epidermis Fluorescent Dyes - pharmacokinetics Genes Genotype In Situ Hybridization Isoquinolines - pharmacokinetics Keratinization Keratinocytes Mice Rodents Skin Skin - growth & development Skin - metabolism Skin Abnormalities - enzymology Skin Abnormalities - mortality Stem cells Transglutaminases - genetics Transglutaminases - physiology
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