Structural Basis for the Interaction of the Fluorescence Probe 8-anilino-1-naphthalene Sulfonate (ANS) with the Antibiotic Target MurA

The extrinsic fluorescence dye 8-anilino-1-naphthalene sulfonate (ANS) is widely used for probing conformational changes in proteins, yet no detailed structure of ANS bound to any protein has been reported so far. ANS has been successfully used to monitor the induced-fit mechanism of MurA [UDPGlcNAc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2000-06, Vol.97 (12), p.6345-6349
Hauptverfasser:	Schonbrunn, Ernst, Eschenburg, Susanne, Luger, Karolin, Kabsch, Wolfgang, Amrhein, Nikolaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases - chemistry Alkyl and Aryl Transferases - metabolism Amino Acid Sequence Anilino Naphthalenesulfonates - metabolism Atoms Binding Sites Biochemistry Biological Sciences Crystals Drug interactions Enzymes Fluorescence Molecular Sequence Data Molecules Proteins Solvents Spectrometry, Fluorescence Sulfonates
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