Role of the p21 Cyclin-Dependent Kinase Inhibitor in Limiting Intimal Cell Proliferation in Response to Arterial Injury

Arterial injury induces a series of proliferative, vasoactive, and inflammatory responses that lead to vascular proliferative diseases, including atherosclerosis and restenosis. Although several factors have been defined which stimulate this process in vivo, the role of specific cellular gene produc...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-07, Vol.93 (15), p.7905-7910
Hauptverfasser:	Yang, Zhi-Yong, Simari, Robert D., Perkins, Neil D., San, Hong, Gordon, David, Nabel, Gary J., Nabel, Elizabeth G.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 cells Adenoviridae Animals Antibodies Arteries Balloons Base Sequence Blood vessels Carrier Proteins - biosynthesis Carrier Proteins - physiology Catheterization Cell Cycle Cell Division Cell growth Cells Cells, Cultured Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinases - antagonists & inhibitors DNA Primers Endothelial cells Endothelium, Vascular - cytology Endothelium, Vascular - injuries Endothelium, Vascular - physiology Femoral Artery Gene therapy Genetic Vectors Hogs Iliac Artery Infections Medical instruments Medical research Molecular Sequence Data Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - injuries Muscle, Smooth, Vascular - physiology Physical trauma Polymerase Chain Reaction Proteins Smooth muscle myocytes Swine Transfection
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