Genetics and visual attention: Selective deficits in healthy adult carriers of the epsilon4 allele of the apolipoprotein E gene

Genetics and visual attention: Selective deficits in healthy adult carriers of the epsilon4 allele of the apolipoprotein E gene

The epsilon4 allele of the apolipoprotein E (APOE) gene is associated with altered brain physiology in healthy adults before old age, but concomitant deficits in cognition on standardized tests of cognitive function have not been consistently demonstrated. We hypothesized that sensitive and specific...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2000-10, Vol.97 (21), p.11661
Hauptverfasser: Greenwood, Pamela M, Sunderland, Trey, Friz, Judy L, Parasuraman, Raja
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Alzheimer's disease
Genetics
Proteins
Psychology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 21
container_start_page 11661
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 97
creator Greenwood, Pamela M
Sunderland, Trey
Friz, Judy L
Parasuraman, Raja
description The epsilon4 allele of the apolipoprotein E (APOE) gene is associated with altered brain physiology in healthy adults before old age, but concomitant deficits in cognition on standardized tests of cognitive function have not been consistently demonstrated. We hypothesized that sensitive and specific assessment of basic attentional functions that underlie complex cognition would reveal evidence of impairment in otherwise asymptomatic individuals.
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_201366991</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>63351832</sourcerecordid><originalsourceid>FETCH-proquest_journals_2013669913</originalsourceid><addsrcrecordid>eNqNjbFOw0AQRE8IJAzhH1b0ltaOY3K0KEAPfXSy13ij1Z25XUei4te5AnqqkWbezFy4qkHf1H3n8dJViO1Dve_a7trdqJ4Q0e_2WLnvF4pkPCiEOMKZdQ0CwYyicYqP8EZCg_GZYKSJBzYFjjBTEJu_IIyrGAwhZ6askCawmYAWZUmxgyBS6n92WJLwkpacjMrGAT7K9cZdTUGU7n711t0_H96fXuuCfa6kdjylNccSHVtstn3vfbP9F_QDg9VRQA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201366991</pqid></control><display><type>article</type><title>Genetics and visual attention: Selective deficits in healthy adult carriers of the epsilon4 allele of the apolipoprotein E gene</title><source>Jstor Complete Legacy</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Greenwood, Pamela M ; Sunderland, Trey ; Friz, Judy L ; Parasuraman, Raja</creator><creatorcontrib>Greenwood, Pamela M ; Sunderland, Trey ; Friz, Judy L ; Parasuraman, Raja</creatorcontrib><description>The epsilon4 allele of the apolipoprotein E (APOE) gene is associated with altered brain physiology in healthy adults before old age, but concomitant deficits in cognition on standardized tests of cognitive function have not been consistently demonstrated. We hypothesized that sensitive and specific assessment of basic attentional functions that underlie complex cognition would reveal evidence of impairment in otherwise asymptomatic individuals.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><language>eng</language><publisher>Washington: National Academy of Sciences</publisher><subject>Aging ; Alzheimer's disease ; Genetics ; Proteins ; Psychology</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2000-10, Vol.97 (21), p.11661</ispartof><rights>Copyright National Academy of Sciences Oct 10, 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781</link.rule.ids></links><search><creatorcontrib>Greenwood, Pamela M</creatorcontrib><creatorcontrib>Sunderland, Trey</creatorcontrib><creatorcontrib>Friz, Judy L</creatorcontrib><creatorcontrib>Parasuraman, Raja</creatorcontrib><title>Genetics and visual attention: Selective deficits in healthy adult carriers of the epsilon4 allele of the apolipoprotein E gene</title><title>Proceedings of the National Academy of Sciences - PNAS</title><description>The epsilon4 allele of the apolipoprotein E (APOE) gene is associated with altered brain physiology in healthy adults before old age, but concomitant deficits in cognition on standardized tests of cognitive function have not been consistently demonstrated. We hypothesized that sensitive and specific assessment of basic attentional functions that underlie complex cognition would reveal evidence of impairment in otherwise asymptomatic individuals.</description><subject>Aging</subject><subject>Alzheimer's disease</subject><subject>Genetics</subject><subject>Proteins</subject><subject>Psychology</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqNjbFOw0AQRE8IJAzhH1b0ltaOY3K0KEAPfXSy13ij1Z25XUei4te5AnqqkWbezFy4qkHf1H3n8dJViO1Dve_a7trdqJ4Q0e_2WLnvF4pkPCiEOMKZdQ0CwYyicYqP8EZCg_GZYKSJBzYFjjBTEJu_IIyrGAwhZ6askCawmYAWZUmxgyBS6n92WJLwkpacjMrGAT7K9cZdTUGU7n711t0_H96fXuuCfa6kdjylNccSHVtstn3vfbP9F_QDg9VRQA</recordid><startdate>20001010</startdate><enddate>20001010</enddate><creator>Greenwood, Pamela M</creator><creator>Sunderland, Trey</creator><creator>Friz, Judy L</creator><creator>Parasuraman, Raja</creator><general>National Academy of Sciences</general><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20001010</creationdate><title>Genetics and visual attention: Selective deficits in healthy adult carriers of the epsilon4 allele of the apolipoprotein E gene</title><author>Greenwood, Pamela M ; Sunderland, Trey ; Friz, Judy L ; Parasuraman, Raja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_2013669913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aging</topic><topic>Alzheimer's disease</topic><topic>Genetics</topic><topic>Proteins</topic><topic>Psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Greenwood, Pamela M</creatorcontrib><creatorcontrib>Sunderland, Trey</creatorcontrib><creatorcontrib>Friz, Judy L</creatorcontrib><creatorcontrib>Parasuraman, Raja</creatorcontrib><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greenwood, Pamela M</au><au>Sunderland, Trey</au><au>Friz, Judy L</au><au>Parasuraman, Raja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetics and visual attention: Selective deficits in healthy adult carriers of the epsilon4 allele of the apolipoprotein E gene</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><date>2000-10-10</date><risdate>2000</risdate><volume>97</volume><issue>21</issue><spage>11661</spage><pages>11661-</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The epsilon4 allele of the apolipoprotein E (APOE) gene is associated with altered brain physiology in healthy adults before old age, but concomitant deficits in cognition on standardized tests of cognitive function have not been consistently demonstrated. We hypothesized that sensitive and specific assessment of basic attentional functions that underlie complex cognition would reveal evidence of impairment in otherwise asymptomatic individuals.</abstract><cop>Washington</cop><pub>National Academy of Sciences</pub></addata></record>
fulltext fulltext
identifier ISSN: 0027-8424
ispartof Proceedings of the National Academy of Sciences - PNAS, 2000-10, Vol.97 (21), p.11661
issn 0027-8424
1091-6490
language eng
recordid cdi_proquest_journals_201366991
source Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry
subjects Aging
Alzheimer's disease
Genetics
Proteins
Psychology
title Genetics and visual attention: Selective deficits in healthy adult carriers of the epsilon4 allele of the apolipoprotein E gene
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T19%3A13%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetics%20and%20visual%20attention:%20Selective%20deficits%20in%20healthy%20adult%20carriers%20of%20the%20epsilon4%20allele%20of%20the%20apolipoprotein%20E%20gene&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Greenwood,%20Pamela%20M&rft.date=2000-10-10&rft.volume=97&rft.issue=21&rft.spage=11661&rft.pages=11661-&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/&rft_dat=%3Cproquest%3E63351832%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201366991&rft_id=info:pmid/&rfr_iscdi=true