Na+-mediated coupling between AMPA receptors and K^sub Na^ channels shapes synaptic transmission
Na...-activated K... (K...) channels are expressed in neurons and are activated by Na... influx through voltage-dependent channels or ionotropic receptors, yet their function remains unclear. Here we show that K... channels are associated with AMPA receptors and that their activation depresses synap...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2008-12, Vol.105 (52), p.20941 |
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| container_issue | 52 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 105 |
| creator | Nanou, Evanthia Kyriakatos, Alexandros Bhattacharjee, Arin Kaczmarek, Leonard K Paratcha, Gustavo El Manira, Abdeljabbar |
| description | Na...-activated K... (K...) channels are expressed in neurons and are activated by Na... influx through voltage-dependent channels or ionotropic receptors, yet their function remains unclear. Here we show that K... channels are associated with AMPA receptors and that their activation depresses synaptic responses. Synaptic activation of K... channels by Na... transients via AMPA receptors shapes the decay of AMPA-mediated current as well as the amplitude of the synaptic potential. Thus, the coupling between K... channels and AMPA receptors by synaptically induced Na... transients represents an inherent negative feedback mechanism that scales down the magnitude of excitatory synaptic responses. (ProQuest: ... denotes formulae/symbols omitted.) |
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(K...) channels are expressed in neurons and are activated by Na... influx through voltage-dependent channels or ionotropic receptors, yet their function remains unclear. Here we show that K... channels are associated with AMPA receptors and that their activation depresses synaptic responses. Synaptic activation of K... channels by Na... transients via AMPA receptors shapes the decay of AMPA-mediated current as well as the amplitude of the synaptic potential. Thus, the coupling between K... channels and AMPA receptors by synaptically induced Na... transients represents an inherent negative feedback mechanism that scales down the magnitude of excitatory synaptic responses. 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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2008-12, Vol.105 (52), p.20941 |
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| language | eng |
| recordid | cdi_proquest_journals_201366077 |
| source | Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Neurons Potassium Sodium |
| title | Na+-mediated coupling between AMPA receptors and K^sub Na^ channels shapes synaptic transmission |
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