Positive allosteric modulators of metabotropic glutamate 1 recetor: Characterization, mechanism of action, and binding site
We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and recombinant metabotropic glutamate 1 (mGlu1) receptors. These compounds did not directly activate mGlu1 receptors but markedly potentiated agonist-stimulated responses, in...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2001-11, Vol.98 (23), p.13402 |
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| container_issue | 23 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 98 |
| creator | Knoflach, Frederic Mutel, Vincent Jolidon, Synese Kew, James N C |
| description | We have identified two chemical series of compounds acting as selective positive allosteric modulators (enhancers) of native and recombinant metabotropic glutamate 1 (mGlu1) receptors. These compounds did not directly activate mGlu1 receptors but markedly potentiated agonist-stimulated responses, increasing potency and maximum efficacy. |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2001-11, Vol.98 (23), p.13402 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_journals_201363615 |
| source | JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Amino acids Biochemistry Enzymes Proteins |
| title | Positive allosteric modulators of metabotropic glutamate 1 recetor: Characterization, mechanism of action, and binding site |
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