Selective Aluminum Passivation for Targeted Immobilization of Single DNA Polymerase Molecules in Zero-Mode Waveguide Nanostructures

Optical nanostructures have enabled the creation of subdiffraction detection volumes for single-molecule fluorescence microscopy. Their applicability is extended by the ability to place molecules in the confined observation volume without interfering with their biological function. Here, we demonstr...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2008-01, Vol.105 (4), p.1176-1181
Hauptverfasser: Korlach, Jonas, Marks, Patrick J., Cicero, Ronald L., Gray, Jeremy J., Murphy, Devon L., Roitman, Daniel B., Pham, Thang T., Otto, Geoff A., Foquet, Mathieu, Turner, Stephen W.
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Sprache:eng
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