Structure and Evolution of Four POU Domain Genes Expressed in Mouse Brain
Four mouse POU domain genomic DNA clones-Brain-1, Brain-2, Brain-4, and Scip-and Brain-2 cDNA, which are expressed in adult brain, were cloned and the coding and noncoding regions of the genes were sequenced. The amino acid sequences of the four POU domains are highly conserved; sequences in other r...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1992-04, Vol.89 (8), p.3280-3284 |
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| creator | Hara, Yoshinobu Rovescalli, Alessandra C. Kim, Yongsok Nirenberg, Marshall |
| description | Four mouse POU domain genomic DNA clones-Brain-1, Brain-2, Brain-4, and Scip-and Brain-2 cDNA, which are expressed in adult brain, were cloned and the coding and noncoding regions of the genes were sequenced. The amino acid sequences of the four POU domains are highly conserved; sequences in other regions of the proteins also are conserved but to a lesser extent. The absence of introns from the coding regions of the four POU domain genes and the similarity of amino acid sequences of the corresponding proteins suggest that the coding region of the ancestral class III POU domain gene lacked introns and therefore may have originated by reverse transcription of a molecule of POU domain mRNA followed by insertion of the cDNA into germ cell genomic DNA. Additional duplications of the ancestral class III POU domain gene (or mRNA) would create the Brain-1, Brain-2, Brain-4, and Scip genes. |
| doi_str_mv | 10.1073/pnas.89.8.3280 |
| format | Article |
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The amino acid sequences of the four POU domains are highly conserved; sequences in other regions of the proteins also are conserved but to a lesser extent. The absence of introns from the coding regions of the four POU domain genes and the similarity of amino acid sequences of the corresponding proteins suggest that the coding region of the ancestral class III POU domain gene lacked introns and therefore may have originated by reverse transcription of a molecule of POU domain mRNA followed by insertion of the cDNA into germ cell genomic DNA. Additional duplications of the ancestral class III POU domain gene (or mRNA) would create the Brain-1, Brain-2, Brain-4, and Scip genes.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.89.8.3280</identifier><identifier>PMID: 1565620</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Amino Acid Sequence ; Amino acids ; Animals ; Base Sequence ; Biological and medical sciences ; Biological Evolution ; Brain ; Brain - physiology ; cDNA ; Cloning, Molecular ; Complementary DNA ; Deoxyribonucleic acid ; DNA ; DNA - genetics ; DNA - isolation & purification ; DNA probes ; DNA-Binding Proteins - genetics ; evolution ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Genes. Genome ; Genetics ; Genomics ; Mice ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Nerve Tissue Proteins - genetics ; Nucleotide sequences ; Nucleotides ; Octamer Transcription Factor-6 ; Oligonucleotide Probes ; Open reading frames ; POU Domain Factors ; Proteins ; RNA ; RNA, Messenger - genetics ; Rodents ; Sequence Homology, Nucleic Acid ; Transcription Factors - genetics</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1992-04, Vol.89 (8), p.3280-3284</ispartof><rights>Copyright 1992 The National Academy of Sciences of the United States of America</rights><rights>1992 INIST-CNRS</rights><rights>Copyright National Academy of Sciences Apr 15, 1992</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5540-f646f662f8c9fd3344af32f0f378b3513ca984466a1b00a268109b6d4793f95a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/89/8.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2359082$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2359082$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,728,781,785,804,886,27928,27929,53795,53797,58021,58254</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5253919$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1565620$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hara, Yoshinobu</creatorcontrib><creatorcontrib>Rovescalli, Alessandra C.</creatorcontrib><creatorcontrib>Kim, Yongsok</creatorcontrib><creatorcontrib>Nirenberg, Marshall</creatorcontrib><title>Structure and Evolution of Four POU Domain Genes Expressed in Mouse Brain</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Four mouse POU domain genomic DNA clones-Brain-1, Brain-2, Brain-4, and Scip-and Brain-2 cDNA, which are expressed in adult brain, were cloned and the coding and noncoding regions of the genes were sequenced. The amino acid sequences of the four POU domains are highly conserved; sequences in other regions of the proteins also are conserved but to a lesser extent. The absence of introns from the coding regions of the four POU domain genes and the similarity of amino acid sequences of the corresponding proteins suggest that the coding region of the ancestral class III POU domain gene lacked introns and therefore may have originated by reverse transcription of a molecule of POU domain mRNA followed by insertion of the cDNA into germ cell genomic DNA. Additional duplications of the ancestral class III POU domain gene (or mRNA) would create the Brain-1, Brain-2, Brain-4, and Scip genes.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>Brain</subject><subject>Brain - physiology</subject><subject>cDNA</subject><subject>Cloning, Molecular</subject><subject>Complementary DNA</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>DNA - isolation & purification</subject><subject>DNA probes</subject><subject>DNA-Binding Proteins - genetics</subject><subject>evolution</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Genes. Genome</subject><subject>Genetics</subject><subject>Genomics</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nucleotide sequences</subject><subject>Nucleotides</subject><subject>Octamer Transcription Factor-6</subject><subject>Oligonucleotide Probes</subject><subject>Open reading frames</subject><subject>POU Domain Factors</subject><subject>Proteins</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>Rodents</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Transcription Factors - genetics</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1vEzEUxC0EKmnhygkkC1W97fL8ubbEBUpaKhUVCXq2nF0bNtrYqb1blf8eRwkhcICTJc9vnj1vEHpBoCbQsDfrYHOtdK1qRhU8QjMCmlSSa3iMZgC0qRSn_Ck6znkJAFooOEJHREghKczQ1ZcxTe04JYdt6PD8Pg7T2MeAo8cXcUr4880t_hBXtg_40gWX8fxhnVzOrsPl6lOcssPvU5GfoSfeDtk9350n6PZi_vX8Y3V9c3l1_u66aoXgUHnJpZeSetVq3zHGufWMevCsUQsmCGutVpxLackCwFKpSqCF7HijmdfCshP0djt3PS1WrmtdGJMdzDr1K5t-mGh786cS-u_mW7w3XCkBxX62s6d4N7k8mlWfWzcMNrgSxjRUaWCE_xckkjSEE1XA13-By7K4UHZgKBDGdUlQoHoLtSnmnJzff5iA2RRpNkUapY0ymyKL4dVhzN_4trmin-50m1s7-GRD2-c9JqhgmuiDMZvxv9TDZ87-pRs_DcPoHsYCvtyCyzzGtCcpExoUZT8BisvFfQ</recordid><startdate>19920415</startdate><enddate>19920415</enddate><creator>Hara, Yoshinobu</creator><creator>Rovescalli, Alessandra C.</creator><creator>Kim, Yongsok</creator><creator>Nirenberg, Marshall</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>M81</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19920415</creationdate><title>Structure and Evolution of Four POU Domain Genes Expressed in Mouse Brain</title><author>Hara, Yoshinobu ; Rovescalli, Alessandra C. ; Kim, Yongsok ; Nirenberg, Marshall</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5540-f646f662f8c9fd3344af32f0f378b3513ca984466a1b00a268109b6d4793f95a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Biological Evolution</topic><topic>Brain</topic><topic>Brain - physiology</topic><topic>cDNA</topic><topic>Cloning, Molecular</topic><topic>Complementary DNA</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA - genetics</topic><topic>DNA - isolation & purification</topic><topic>DNA probes</topic><topic>DNA-Binding Proteins - genetics</topic><topic>evolution</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Genes. Genome</topic><topic>Genetics</topic><topic>Genomics</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nucleotide sequences</topic><topic>Nucleotides</topic><topic>Octamer Transcription Factor-6</topic><topic>Oligonucleotide Probes</topic><topic>Open reading frames</topic><topic>POU Domain Factors</topic><topic>Proteins</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>Rodents</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hara, Yoshinobu</creatorcontrib><creatorcontrib>Rovescalli, Alessandra C.</creatorcontrib><creatorcontrib>Kim, Yongsok</creatorcontrib><creatorcontrib>Nirenberg, Marshall</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Biochemistry Abstracts 3</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hara, Yoshinobu</au><au>Rovescalli, Alessandra C.</au><au>Kim, Yongsok</au><au>Nirenberg, Marshall</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure and Evolution of Four POU Domain Genes Expressed in Mouse Brain</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1992-04-15</date><risdate>1992</risdate><volume>89</volume><issue>8</issue><spage>3280</spage><epage>3284</epage><pages>3280-3284</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Four mouse POU domain genomic DNA clones-Brain-1, Brain-2, Brain-4, and Scip-and Brain-2 cDNA, which are expressed in adult brain, were cloned and the coding and noncoding regions of the genes were sequenced. The amino acid sequences of the four POU domains are highly conserved; sequences in other regions of the proteins also are conserved but to a lesser extent. The absence of introns from the coding regions of the four POU domain genes and the similarity of amino acid sequences of the corresponding proteins suggest that the coding region of the ancestral class III POU domain gene lacked introns and therefore may have originated by reverse transcription of a molecule of POU domain mRNA followed by insertion of the cDNA into germ cell genomic DNA. Additional duplications of the ancestral class III POU domain gene (or mRNA) would create the Brain-1, Brain-2, Brain-4, and Scip genes.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>1565620</pmid><doi>10.1073/pnas.89.8.3280</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amino Acid Sequence Amino acids Animals Base Sequence Biological and medical sciences Biological Evolution Brain Brain - physiology cDNA Cloning, Molecular Complementary DNA Deoxyribonucleic acid DNA DNA - genetics DNA - isolation & purification DNA probes DNA-Binding Proteins - genetics evolution Fundamental and applied biological sciences. Psychology Gene Expression Genes. Genome Genetics Genomics Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Nerve Tissue Proteins - genetics Nucleotide sequences Nucleotides Octamer Transcription Factor-6 Oligonucleotide Probes Open reading frames POU Domain Factors Proteins RNA RNA, Messenger - genetics Rodents Sequence Homology, Nucleic Acid Transcription Factors - genetics |
| title | Structure and Evolution of Four POU Domain Genes Expressed in Mouse Brain |
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