Chimeric Papillomavirus Virus-Like Particles Elicit Antitumor Immunity against the E7 Oncoprotein in an HPV16 Tumor Model

Papillomavirus-like particles (VLPs) are a promising prophylactic vaccine candidate to prevent human papillomavirus (HPV) infections and associated epithelial neoplasia. However, they are unlikely to have therapeutic effects because the virion capsid proteins are not detected in the proliferating ce...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-02, Vol.95 (4), p.1800-1805
Hauptverfasser:	Greenstone, Heather L., Nieland, John D., De Visser, Karin E., Marloes L. H. De Bruijn, Kirnbauer, Reinhard, Richard B. S. Roden, Lowy, Douglas R., Kast, W. Martin, Schiller, John T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Viral - biosynthesis Antiserum Baculoviridae Biological Sciences Capsid - genetics Capsid Proteins Cell Line Cell Membrane - metabolism Chimera Chimeras Genes, Viral Immunity, Cellular Immunology Medical treatment Mice Mice, Inbred C57BL Neoplasms, Experimental - immunology Neutralization Tests Oncogene Proteins, Viral - genetics Oncogene Proteins, Viral - immunology Papillomaviridae - immunology Papillomavirus E7 Proteins Precipitin Tests Proteins Receptors, Virus - immunology Spodoptera Tumors Vaccination Vaccines Vaccines, Synthetic - immunology Viral Structural Proteins - genetics Viral Vaccines - immunology Virions Viruses
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