Insulin Receptor Substrate 1 is Required for Insulin-Mediated Mitogenic Signal Transduction

Insulin treatment of mammalian cells immediately stimulates the tyrosine phosphorylation of a cellular protein of 185 kDa referred to as pp185 or IRS-1 (insulin receptor substrate 1). The potential role of the IRS-1 protein in insulin signaling has been examined by microinjecting affinity-purified a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-01, Vol.91 (2), p.797-801
Hauptverfasser:	Rose, David W., Saltiel, Alan R., Majumdar, Mousumi, Decker, Stuart J., Olefsky, Jerrold M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies Antibodies - administration & dosage Biological and medical sciences Cell cycle Cell Division - drug effects Cell Division - physiology Cell growth Cell Line Cell lines Cell physiology Cells Cellular biology DNA DNA - biosynthesis Epidermal Growth Factor - pharmacology Fibroblast Growth Factor 2 - pharmacology Fundamental and applied biological sciences. Psychology Humans Insulin Insulin - metabolism Insulin - pharmacology Insulin Receptor Substrate Proteins Insulin-Like Growth Factor I - pharmacology Microinjections Molecular and cellular biology Molecular Sequence Data Phosphoproteins - antagonists & inhibitors Phosphoproteins - genetics Phosphoproteins - metabolism Proteins Rats Receptor, Insulin - genetics Receptor, Insulin - metabolism Receptors Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Transfection
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