vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4⁺ T cell depletion in SHIV-infected macaques
We previously showed that a gp41 peptide (3S) induces expression of a natural killer (NK) ligand (NKp44L) on CD4⁺ T cells during HIV-1 infection and that those cells are highly sensitive to NK lysis. In HIV-infected patients, anti-3S antibodies are associated with the maintenance of CD4⁺ T cell coun...
Gespeichert in:
| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2008-02, Vol.105 (6), p.2100-2104 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2104 |
|---|---|
| container_issue | 6 |
| container_start_page | 2100 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 105 |
| creator | Vieillard, Vincent Le Grand, Roger Dausset, Jean Debré, Patrice |
| description | We previously showed that a gp41 peptide (3S) induces expression of a natural killer (NK) ligand (NKp44L) on CD4⁺ T cells during HIV-1 infection and that those cells are highly sensitive to NK lysis. In HIV-infected patients, anti-3S antibodies are associated with the maintenance of CD4⁺ T cell counts close to their baseline values, and CD4⁺ T cells decrease with the antibody titer. This study sought to determine whether anti-3S immunization could prevent NKp44L expression on these CD4⁺ T cells in vivo and inhibits the subsequent decline in CD4⁺ T cell counts by immunizing macaques with 3S and then infecting them with simian HIV₁₆₂P₃. The results show that anti-3S antibodies inhibited NKp44L expression and NK activity and cytotoxicity. They also decreased the apoptosis rate of CD4⁺ T cells in peripheral blood and lymph nodes. These data raise questions about the pathogenesis of HIV and present opportunities for both preventive and therapeutic HIV vaccine strategies. |
| doi_str_mv | 10.1073/pnas.0711629105 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_journals_201344197</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>25451420</jstor_id><sourcerecordid>25451420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-5617e1c799bae5206ed3ace519c1a0b317745d4cbde7309e7f10eed238d229883</originalsourceid><addsrcrecordid>eNp9kcFu1DAURSMEokNhzQqwWMAqre3YccwCaTQFOmIEi2nZWh7nZfAocdLYGbXs-AO-h8_hS3CYUaewYGXJ97yrd99NkqcEnxAsstPOaX-CBSE5lQTze8mEYEnSnEl8P5lgTEVaMMqOkkfebzDGkhf4YXJECpqxgvNJ8mOrjbEOkA-9DrC-QXqtrfMBTednyzdo6tD5_Atad4ygDrpgS0C2aQZnv-lgW4e6HrbggkefPnaMLRBcxx_vR0m7Es3O2K_vP9EFMlDXqISuhj9j1qFlNE6tq8AEKFGjjb4awD9OHlS69vBk_x4nl-_fXczO08XnD_PZdJEaTmRIeU4EECOkXGngFOdQZtpA1AzReJURIRgvmVmVIDIsQVQEA5Q0K0pKZVFkx8nbnW83rBooTczQ61p1vW10f6NabdXfirNf1brdKsoZLXIZDV7tDfp2XDyoxvoxpXbQDl4JTKVghETw5T_gph16F8MpiknGGJEiQqc7yPSt9z1Ut5sQrMaq1Vi1OlQdJ57fDXDg993eAcbJgx1XuaIE4wi8_i-gqqGuA1yHSD7bkRsf2v4WjafghNHR6cVOr3Sr9Lq3Xl0ux3AYF1xKzLLfmfrQxw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>201344197</pqid></control><display><type>article</type><title>vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4⁺ T cell depletion in SHIV-infected macaques</title><source>MEDLINE</source><source>Jstor Complete Legacy</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Vieillard, Vincent ; Le Grand, Roger ; Dausset, Jean ; Debré, Patrice</creator><creatorcontrib>Vieillard, Vincent ; Le Grand, Roger ; Dausset, Jean ; Debré, Patrice</creatorcontrib><description>We previously showed that a gp41 peptide (3S) induces expression of a natural killer (NK) ligand (NKp44L) on CD4⁺ T cells during HIV-1 infection and that those cells are highly sensitive to NK lysis. In HIV-infected patients, anti-3S antibodies are associated with the maintenance of CD4⁺ T cell counts close to their baseline values, and CD4⁺ T cells decrease with the antibody titer. This study sought to determine whether anti-3S immunization could prevent NKp44L expression on these CD4⁺ T cells in vivo and inhibits the subsequent decline in CD4⁺ T cell counts by immunizing macaques with 3S and then infecting them with simian HIV₁₆₂P₃. The results show that anti-3S antibodies inhibited NKp44L expression and NK activity and cytotoxicity. They also decreased the apoptosis rate of CD4⁺ T cells in peripheral blood and lymph nodes. These data raise questions about the pathogenesis of HIV and present opportunities for both preventive and therapeutic HIV vaccine strategies.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0711629105</identifier><identifier>PMID: 18234855</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>AIDS Vaccines - immunology ; Animal vaccines ; Animals ; Antibodies ; Apoptosis ; Biological Sciences ; CD4-Positive T-Lymphocytes - immunology ; Cell lines ; Cytotoxicity ; Gene expression ; HIV ; HIV Envelope Protein gp41 - immunology ; HIV Infections - immunology ; Human immunodeficiency virus ; Immunization ; Infections ; Killer Cells, Natural - immunology ; Ligands ; Lymph nodes ; Lymphocyte Depletion ; Macaca fascicularis ; Monkeys & apes ; Natural killer cells ; Peptides ; Simian Acquired Immunodeficiency Syndrome - immunology ; Studies ; T lymphocytes</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (6), p.2100-2104</ispartof><rights>Copyright 2008 The National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Feb 12, 2008</rights><rights>2008 by The National Academy of Sciences of the USA</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-5617e1c799bae5206ed3ace519c1a0b317745d4cbde7309e7f10eed238d229883</citedby><cites>FETCH-LOGICAL-c519t-5617e1c799bae5206ed3ace519c1a0b317745d4cbde7309e7f10eed238d229883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/105/6.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25451420$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25451420$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,724,777,781,800,882,27905,27906,53772,53774,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18234855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vieillard, Vincent</creatorcontrib><creatorcontrib>Le Grand, Roger</creatorcontrib><creatorcontrib>Dausset, Jean</creatorcontrib><creatorcontrib>Debré, Patrice</creatorcontrib><title>vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4⁺ T cell depletion in SHIV-infected macaques</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>We previously showed that a gp41 peptide (3S) induces expression of a natural killer (NK) ligand (NKp44L) on CD4⁺ T cells during HIV-1 infection and that those cells are highly sensitive to NK lysis. In HIV-infected patients, anti-3S antibodies are associated with the maintenance of CD4⁺ T cell counts close to their baseline values, and CD4⁺ T cells decrease with the antibody titer. This study sought to determine whether anti-3S immunization could prevent NKp44L expression on these CD4⁺ T cells in vivo and inhibits the subsequent decline in CD4⁺ T cell counts by immunizing macaques with 3S and then infecting them with simian HIV₁₆₂P₃. The results show that anti-3S antibodies inhibited NKp44L expression and NK activity and cytotoxicity. They also decreased the apoptosis rate of CD4⁺ T cells in peripheral blood and lymph nodes. These data raise questions about the pathogenesis of HIV and present opportunities for both preventive and therapeutic HIV vaccine strategies.</description><subject>AIDS Vaccines - immunology</subject><subject>Animal vaccines</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Apoptosis</subject><subject>Biological Sciences</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>Cell lines</subject><subject>Cytotoxicity</subject><subject>Gene expression</subject><subject>HIV</subject><subject>HIV Envelope Protein gp41 - immunology</subject><subject>HIV Infections - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Immunization</subject><subject>Infections</subject><subject>Killer Cells, Natural - immunology</subject><subject>Ligands</subject><subject>Lymph nodes</subject><subject>Lymphocyte Depletion</subject><subject>Macaca fascicularis</subject><subject>Monkeys & apes</subject><subject>Natural killer cells</subject><subject>Peptides</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Studies</subject><subject>T lymphocytes</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAURSMEokNhzQqwWMAqre3YccwCaTQFOmIEi2nZWh7nZfAocdLYGbXs-AO-h8_hS3CYUaewYGXJ97yrd99NkqcEnxAsstPOaX-CBSE5lQTze8mEYEnSnEl8P5lgTEVaMMqOkkfebzDGkhf4YXJECpqxgvNJ8mOrjbEOkA-9DrC-QXqtrfMBTednyzdo6tD5_Atad4ygDrpgS0C2aQZnv-lgW4e6HrbggkefPnaMLRBcxx_vR0m7Es3O2K_vP9EFMlDXqISuhj9j1qFlNE6tq8AEKFGjjb4awD9OHlS69vBk_x4nl-_fXczO08XnD_PZdJEaTmRIeU4EECOkXGngFOdQZtpA1AzReJURIRgvmVmVIDIsQVQEA5Q0K0pKZVFkx8nbnW83rBooTczQ61p1vW10f6NabdXfirNf1brdKsoZLXIZDV7tDfp2XDyoxvoxpXbQDl4JTKVghETw5T_gph16F8MpiknGGJEiQqc7yPSt9z1Ut5sQrMaq1Vi1OlQdJ57fDXDg993eAcbJgx1XuaIE4wi8_i-gqqGuA1yHSD7bkRsf2v4WjafghNHR6cVOr3Sr9Lq3Xl0ux3AYF1xKzLLfmfrQxw</recordid><startdate>20080212</startdate><enddate>20080212</enddate><creator>Vieillard, Vincent</creator><creator>Le Grand, Roger</creator><creator>Dausset, Jean</creator><creator>Debré, Patrice</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080212</creationdate><title>vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4⁺ T cell depletion in SHIV-infected macaques</title><author>Vieillard, Vincent ; Le Grand, Roger ; Dausset, Jean ; Debré, Patrice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-5617e1c799bae5206ed3ace519c1a0b317745d4cbde7309e7f10eed238d229883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>AIDS Vaccines - immunology</topic><topic>Animal vaccines</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Apoptosis</topic><topic>Biological Sciences</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>Cell lines</topic><topic>Cytotoxicity</topic><topic>Gene expression</topic><topic>HIV</topic><topic>HIV Envelope Protein gp41 - immunology</topic><topic>HIV Infections - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Immunization</topic><topic>Infections</topic><topic>Killer Cells, Natural - immunology</topic><topic>Ligands</topic><topic>Lymph nodes</topic><topic>Lymphocyte Depletion</topic><topic>Macaca fascicularis</topic><topic>Monkeys & apes</topic><topic>Natural killer cells</topic><topic>Peptides</topic><topic>Simian Acquired Immunodeficiency Syndrome - immunology</topic><topic>Studies</topic><topic>T lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vieillard, Vincent</creatorcontrib><creatorcontrib>Le Grand, Roger</creatorcontrib><creatorcontrib>Dausset, Jean</creatorcontrib><creatorcontrib>Debré, Patrice</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vieillard, Vincent</au><au>Le Grand, Roger</au><au>Dausset, Jean</au><au>Debré, Patrice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4⁺ T cell depletion in SHIV-infected macaques</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2008-02-12</date><risdate>2008</risdate><volume>105</volume><issue>6</issue><spage>2100</spage><epage>2104</epage><pages>2100-2104</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>We previously showed that a gp41 peptide (3S) induces expression of a natural killer (NK) ligand (NKp44L) on CD4⁺ T cells during HIV-1 infection and that those cells are highly sensitive to NK lysis. In HIV-infected patients, anti-3S antibodies are associated with the maintenance of CD4⁺ T cell counts close to their baseline values, and CD4⁺ T cells decrease with the antibody titer. This study sought to determine whether anti-3S immunization could prevent NKp44L expression on these CD4⁺ T cells in vivo and inhibits the subsequent decline in CD4⁺ T cell counts by immunizing macaques with 3S and then infecting them with simian HIV₁₆₂P₃. The results show that anti-3S antibodies inhibited NKp44L expression and NK activity and cytotoxicity. They also decreased the apoptosis rate of CD4⁺ T cells in peripheral blood and lymph nodes. These data raise questions about the pathogenesis of HIV and present opportunities for both preventive and therapeutic HIV vaccine strategies.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>18234855</pmid><doi>10.1073/pnas.0711629105</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (6), p.2100-2104 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_journals_201344197 |
| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | AIDS Vaccines - immunology Animal vaccines Animals Antibodies Apoptosis Biological Sciences CD4-Positive T-Lymphocytes - immunology Cell lines Cytotoxicity Gene expression HIV HIV Envelope Protein gp41 - immunology HIV Infections - immunology Human immunodeficiency virus Immunization Infections Killer Cells, Natural - immunology Ligands Lymph nodes Lymphocyte Depletion Macaca fascicularis Monkeys & apes Natural killer cells Peptides Simian Acquired Immunodeficiency Syndrome - immunology Studies T lymphocytes |
| title | vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4⁺ T cell depletion in SHIV-infected macaques |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T12%3A04%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=vaccine%20strategy%20against%20AIDS:%20An%20HIV%20gp41%20peptide%20immunization%20prevents%20NKp44L%20expression%20and%20CD4%E2%81%BA%20T%20cell%20depletion%20in%20SHIV-infected%20macaques&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Vieillard,%20Vincent&rft.date=2008-02-12&rft.volume=105&rft.issue=6&rft.spage=2100&rft.epage=2104&rft.pages=2100-2104&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.0711629105&rft_dat=%3Cjstor_proqu%3E25451420%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=201344197&rft_id=info:pmid/18234855&rft_jstor_id=25451420&rfr_iscdi=true |