Caffeine and acetaminophen association: Effects on mitochondrial bioenergetics

Many studies have been demonstrating the role of mitochondrial function in acetaminophen (APAP) hepatotoxicity. Since APAP is commonly consumed with caffeine, this work evaluated the effects of the combination of APAP and caffeine on hepatic mitochondrial bioenergetic function in mice. Mice were tre...

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Veröffentlicht in:	Life sciences (1973) 2018-01, Vol.193, p.234-241
Hauptverfasser:	Gonçalves, Débora F., de Carvalho, Nelson R., Leite, Martim B., Courtes, Aline A., Hartmann, Diane D., Stefanello, Sílvio T., da Silva, Ingrid K., Franco, Jéferson L., Soares, Félix A.A., Dalla Corte, Cristiane L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - metabolism Acetaminophen - pharmacology Acetaminophen - toxicity Animals Antioxidants Antioxidants - pharmacology Bioenergetics Caffeine Caffeine - metabolism Caffeine - pharmacology Chemical and Drug Induced Liver Injury - metabolism Energy Metabolism - drug effects Glutathione Hepatocytes - drug effects Hepatotoxicity High-resolution respirometry Lipid Peroxidation Liver - drug effects Male Mice Mitochondria Mitochondria - drug effects Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Oxidative stress Oxidative Stress - drug effects Oxygen Oxygen consumption Peroxidation Reactive oxygen species Reactive Oxygen Species - metabolism Respirometry Rodents
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