Positive Genetic Feedback Governs cAMP Spiral Wave Formation in Dictyostelium

The aggregation stage of the life cycle of Dictyostelium discoideum is governed by the chemotactic response of individual amoebae to excitable waves of cAMP. We modeled this process through a recently introduced hybrid automata-continuum scheme and used computer simulation to unravel the role of spe...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-06, Vol.93 (13), p.6382-6386
Hauptverfasser:	Levine, Herbert, Aranson, Igor, Tsimring, Lev, Truong, Thai Viet
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregation Animals Cell aggregates Cell motility Chemotaxis Cyclic AMP - metabolism Developmental biology Dictyostelium - genetics Dictyostelium - metabolism Dictyostelium - physiology Dictyostelium discoideum Evolutionary genetics Genes Genetics Models, Genetic Organisms Physics Positive feedback Receptors Refractory periods Signal Transduction
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