Induction of Colitis Causes Inflammatory Responses in Fat Depots: Evidence for Substance P Pathways in Human Mesenteric Preadipocytes

Intracolonic administration of trinitrobenzene sulfonic acid in mice causes inflammation in the colon that is accompanied by increased expression of proinflammatory cytokines and of the substance P (SP), neurokinin 1 receptor (NK-1R) in the proximal mesenteric fat depot. We also investigated whether...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-03, Vol.103 (13), p.5207-5212
Hauptverfasser:	Karagiannides, Iordanes, Kokkotou, Efi, Tansky, Morris, Tchkonia, Tamara, Giorgadze, Nino, O'Brien, Michael, Leeman, Susan E., Kirkland, James L., Pothoulakis, Charalabos
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Fat - drug effects Abdominal Fat - metabolism Abdominal Fat - pathology Abdominal Fat - secretion Adipocytes Adipose tissues Animals Biological Sciences Body fat Bowel disease Cell Differentiation Cells, Cultured Cellular biology Chemotaxis Colitis Colitis - chemically induced Colitis - metabolism Colitis - pathology Colon Cytokines Cytokines - biosynthesis Cytokines - genetics Cytokines - secretion Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation - drug effects Humans Inflammation Keratinocytes - cytology Keratinocytes - metabolism Macrophages Mesentery - drug effects Mesentery - metabolism Mesentery - pathology Messenger RNA Mice NF-kappa B - metabolism Phosphorylation - drug effects Receptors Receptors, Neurokinin-1 - metabolism RNA RNA, Messenger - genetics Rodents Signal Transduction Substance P - metabolism Substance P - pharmacology Time Factors Trinitrobenzenesulfonic Acid - administration & dosage Trinitrobenzenesulfonic Acid - pharmacology
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