Mutations That Affect the Ability of the vnd/NK-2 Homeoprotein to Regulate Gene Expression: Transgenic Alterations and Tertiary Structure

The importance in downstream target regulation of tertiary structure and DNA binding specificity of the protein encoded by the vnd/NK-2 homeobox gene is analyzed. The ectopic expression patterns of WT and four mutant vnd/NK-2 genes are analyzed together with expression of two downstream target genes...

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