A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins

The Na+/H+ exchanger regulatory factor (NHERF) binds to the tail of the beta2-adrenergic receptor and plays a role in adrenergic regulation of Na+/H+ exchange. NHERF contains two PDZ domains, the first of which is required for its interaction with the beta2 receptor. Mutagenesis studies of the beta2...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-07, Vol.95 (15), p.8496
Hauptverfasser:	Hall, R A, Ostedgaard, L S, Premont, R T, Blitzer, J T, Rahman, N, Welsh, M J, Lefkowitz, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biochemistry Cloning, Molecular Cystic fibrosis Cystic Fibrosis Transmembrane Conductance Regulator - chemistry Cystic Fibrosis Transmembrane Conductance Regulator - metabolism DNA Primers Humans Molecular Sequence Data Phosphoproteins - chemistry Phosphoproteins - genetics Phosphoproteins - metabolism Protein Binding Proteins Receptors, Adrenergic, beta-2 - chemistry Receptors, Adrenergic, beta-2 - metabolism Receptors, Purinergic P2 - chemistry Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y1 Sequence Homology, Amino Acid Sodium-Hydrogen Exchangers - metabolism
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