genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories
Emotionally arousing events are typically well remembered, but there is a large interindividual variability for this phenomenon. We have recently shown that a functional deletion variant of ADRA2B, the gene encoding the α2b-adrenergic receptor, is related to enhanced emotional memory in healthy huma...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2009-11, Vol.106 (45), p.19191-19196 |
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| container_issue | 45 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Rasch, B Spalek, K Buholzer, S Luechinger, R Boesiger, P Papassotiropoulos, A de Quervain, D.J.-F |
| description | Emotionally arousing events are typically well remembered, but there is a large interindividual variability for this phenomenon. We have recently shown that a functional deletion variant of ADRA2B, the gene encoding the α2b-adrenergic receptor, is related to enhanced emotional memory in healthy humans and enhanced traumatic memory in war victims. Here, we investigated the neural mechanisms of this effect in healthy participants by using fMRI. Carriers of the ADRA2B deletion variant exhibited increased activation of the amygdala during encoding of photographs with negative emotional valence compared with noncarriers of the deletion. Additionally, functional connectivity between amygdala and insula was significantly stronger in deletion carriers. The present findings indicate that the ADRA2B deletion variant is related to increased responsivity and connectivity of brain regions implicated in emotional memory. |
| doi_str_mv | 10.1073/pnas.0907425106 |
| format | Article |
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We have recently shown that a functional deletion variant of ADRA2B, the gene encoding the α2b-adrenergic receptor, is related to enhanced emotional memory in healthy humans and enhanced traumatic memory in war victims. Here, we investigated the neural mechanisms of this effect in healthy participants by using fMRI. Carriers of the ADRA2B deletion variant exhibited increased activation of the amygdala during encoding of photographs with negative emotional valence compared with noncarriers of the deletion. Additionally, functional connectivity between amygdala and insula was significantly stronger in deletion carriers. The present findings indicate that the ADRA2B deletion variant is related to increased responsivity and connectivity of brain regions implicated in emotional memory.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.0907425106</identifier><identifier>PMID: 19826083</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adult ; Amygdala ; Amygdala - physiology ; Behavioral neuroscience ; Biological Sciences ; Biological variation ; Brain ; Connectivity ; Effects ; Emotional expression ; Emotions ; Emotions - physiology ; Female ; Genes ; Genetic Variation ; Genotypes ; Humans ; Magnetic Resonance Imaging ; Male ; Memory ; Memory - physiology ; Memory encoding ; NMR ; Nuclear magnetic resonance ; Photic Stimulation ; Post traumatic stress disorder ; Psychological stress ; Receptors, Adrenergic, alpha-2 - genetics ; Sequence Deletion</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (45), p.19191-19196</ispartof><rights>Copyright National Academy of Sciences Nov 10, 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c621t-e2ac36f6b08eb0bf673df2eae42747483138376892575a15ca36f2a760bc48ab3</citedby><cites>FETCH-LOGICAL-c621t-e2ac36f6b08eb0bf673df2eae42747483138376892575a15ca36f2a760bc48ab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/106/45.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/25593165$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/25593165$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27922,27923,53789,53791,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19826083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rasch, B</creatorcontrib><creatorcontrib>Spalek, K</creatorcontrib><creatorcontrib>Buholzer, S</creatorcontrib><creatorcontrib>Luechinger, R</creatorcontrib><creatorcontrib>Boesiger, P</creatorcontrib><creatorcontrib>Papassotiropoulos, A</creatorcontrib><creatorcontrib>de Quervain, D.J.-F</creatorcontrib><title>genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Emotionally arousing events are typically well remembered, but there is a large interindividual variability for this phenomenon. We have recently shown that a functional deletion variant of ADRA2B, the gene encoding the α2b-adrenergic receptor, is related to enhanced emotional memory in healthy humans and enhanced traumatic memory in war victims. Here, we investigated the neural mechanisms of this effect in healthy participants by using fMRI. Carriers of the ADRA2B deletion variant exhibited increased activation of the amygdala during encoding of photographs with negative emotional valence compared with noncarriers of the deletion. Additionally, functional connectivity between amygdala and insula was significantly stronger in deletion carriers. The present findings indicate that the ADRA2B deletion variant is related to increased responsivity and connectivity of brain regions implicated in emotional memory.</description><subject>Adult</subject><subject>Amygdala</subject><subject>Amygdala - physiology</subject><subject>Behavioral neuroscience</subject><subject>Biological Sciences</subject><subject>Biological variation</subject><subject>Brain</subject><subject>Connectivity</subject><subject>Effects</subject><subject>Emotional expression</subject><subject>Emotions</subject><subject>Emotions - physiology</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic Variation</subject><subject>Genotypes</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Memory</subject><subject>Memory - physiology</subject><subject>Memory encoding</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Photic Stimulation</subject><subject>Post traumatic stress disorder</subject><subject>Psychological stress</subject><subject>Receptors, Adrenergic, alpha-2 - genetics</subject><subject>Sequence Deletion</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb2P1DAQxSME4paDmgqw6Cj2bvwR22mQ0Ikv6SQKuNqaJE7OqyRebGfFtvzlOMrqFirkwiO937yZ0SuKlxSuKCh-vZ8wXkEFSrCSgnxUbChUdCtFBY-LDQBTWy2YuCiexbgDgKrU8LS4oJVmEjTfFL97O9nkGnLA4DA5PxHfkXRvyeQDtiGroc9yPMZkR-IiCXbAZFuSPGld19mMJIcDwfHYtzggwSa5w2rVzsFNPbFT49ulyNZ29IuUG8ZcBmfj8-JJh0O0L07_ZXH36eOPmy_b22-fv958uN02ktG0tQwbLjtZg7Y11J1UvO2YRSuYEkpoTrnmSuqKlapEWjaYaYZKQt0IjTW_LN6vvvu5Hm3b5L0DDmYf3IjhaDw6868yuXvT-4NhSlImaDZ4ezII_udsYzI7P4d8SjQMKGdCVjpD1yvUBB9jsN3DAApmycwsmZlzZrnj9d97nflTSBl4dwKWzrOdNKLMVH6mm4ch2V8ps-Q_bEZercguJh8eGFaWFaeyzPqbVe_QG-yDi-bu-3IgUAVMQ8X_AE4uwdQ</recordid><startdate>20091110</startdate><enddate>20091110</enddate><creator>Rasch, B</creator><creator>Spalek, K</creator><creator>Buholzer, S</creator><creator>Luechinger, R</creator><creator>Boesiger, P</creator><creator>Papassotiropoulos, A</creator><creator>de Quervain, D.J.-F</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20091110</creationdate><title>genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories</title><author>Rasch, B ; 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| subjects | Adult Amygdala Amygdala - physiology Behavioral neuroscience Biological Sciences Biological variation Brain Connectivity Effects Emotional expression Emotions Emotions - physiology Female Genes Genetic Variation Genotypes Humans Magnetic Resonance Imaging Male Memory Memory - physiology Memory encoding NMR Nuclear magnetic resonance Photic Stimulation Post traumatic stress disorder Psychological stress Receptors, Adrenergic, alpha-2 - genetics Sequence Deletion |
| title | genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories |
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