Metabolic Evolution of Energy-Conserving Pathways for Succinate Production in Escherichia coli

During metabolic evolution to improve succinate production in Escherichia coli strains, significant changes in cellular metabolism were acquired that increased energy efficiency in two respects. The energy-conserving phosphoenolpyruvate (PEP) carboxykinase (pck), which normally functions in the reve...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (48), p.20180-20185
Hauptverfasser:	Zhang, Xueli, Jantama, Kaemwich, Moore, Jonathan C., Jarboe, Laura R., Shanmugam, Keelnatham T., Ingram, Lonnie O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Adenosine Triphosphate - metabolism Biological Sciences Calcium-Binding Proteins - metabolism Carbon Dioxide - metabolism Carboxylation Cellular metabolism E coli Energy metabolism Enzymes Escherichia coli Escherichia coli - metabolism Escherichia coli Proteins - genetics Evolution Evolution, Molecular Fermentation Gene expression Gene Expression Regulation, Enzymologic - genetics Genetic mutation Glucose Industrial Microbiology - methods Metabolism Monosaccharide Transport Proteins - genetics Monosaccharide Transport Proteins - metabolism Mutation - genetics Periplasmic Binding Proteins - metabolism Phosphoenolpyruvate Carboxykinase (ATP) - metabolism Phosphoenolpyruvate Sugar Phosphotransferase System - genetics Rumen bacteria Succinic Acid - metabolism
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