Increased Tricarboxylic Acid Cycle Flux in Rat Brain during Forepaw Stimulation Detected with 1H [13C] NMR

NMR spectroscopy was used to test recent proposals that the additional energy required for brain activation is provided through nonoxidative glycolysis. Using localized NMR spectroscopic methods, the rate of C4-glutamate isotopic turnover from infused [1-13C]glucose was measured in the somatosensory...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-07, Vol.93 (15), p.7612-7617
Hauptverfasser:	Hyder, Fahmeed, Chase, Jennifer R., Behar, Kevin L., Mason, Graeme F., Siddeek, Mohamed, Rothman, Douglas L., Shulman, Robert G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood flow Blood plasma Brain Brain - metabolism Brain - physiology Carbon Isotopes Citric Acid Cycle Electric Stimulation Forelimb Glucose - metabolism Glutamic Acid - metabolism Glycolysis Hydrogen Ketone bodies Kinetics Lactates Magnetic resonance imaging Magnetic Resonance Spectroscopy - methods Male Metabolism Models, Theoretical Motor Cortex - metabolism NMR Nuclear magnetic resonance Occipital Lobe - metabolism Oxygen Oxygen metabolism Rats Rats, Sprague-Dawley Rodents Skin - innervation Somatosensory cortex Somatosensory Cortex - metabolism Sugar
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